{"title":"Tumor-Selective Nano-Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll-Like Receptors (Small 1/2025)","authors":"Yang Liu, Hui Li, Yan-Yun Hao, Ling-Ling Huang, Xia Li, Jing Zou, Shi-Ying Zhang, Xiao-Yue Yang, Hong-Fei Chen, Yi-Xuan Guo, Yun-Yan Guan, Zhi-Yue Zhang","doi":"10.1002/smll.202570005","DOIUrl":null,"url":null,"abstract":"<p><b>Tumor-Selective Delivery</b></p><p>In article number 2406870, Zhi-Yue Zhang and co-workers developed a nano-dispatcher to facilitate tumor-selective co-delivery of a monocarboxylate transporter 4 (MCT4) inhibitor and a TLR7/8 agonist. This approach enhances the immunotherapeutic effect by synergistically regulating lactate metabolism and activating dendritic cells.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202570005","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/smll.202570005","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Tumor-Selective Delivery
In article number 2406870, Zhi-Yue Zhang and co-workers developed a nano-dispatcher to facilitate tumor-selective co-delivery of a monocarboxylate transporter 4 (MCT4) inhibitor and a TLR7/8 agonist. This approach enhances the immunotherapeutic effect by synergistically regulating lactate metabolism and activating dendritic cells.
期刊介绍：
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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