Glioblastoma–neuron networks

IF 21.2 1区 医学 Q1 NEUROSCIENCES Nature neuroscience Pub Date : 2025-01-08 DOI:10.1038/s41593-024-01862-6
Shari Wiseman
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Glioblastoma-neuron网络
胶质瘤细胞可以接受来自神经元的突触输入,但神经元-胶质瘤连接组突触类型的空间范围和多样性尚不清楚。Tetzlaff, Reyhan及其同事在最近的Cell杂志上发表的一篇论文中,使用了一种改良的基于狂犬病病毒的逆行追踪方法,在患者来源的胶质母细胞瘤球形培养物中可视化神经肿瘤网络,这些培养物要么与人类器官型脑切片共培养,要么移植到小鼠大脑中。实时成像显示,在共培养中,神经元和肿瘤之间的功能连接在数小时内发生,在异种移植模型中,在数天内发生。肿瘤连接神经元在多种电生理和形态学测量中显示正常。单个肿瘤的侵袭性评分(来自单细胞rna测序数据)与它们形成突触的能力相关。异种移植物接受全脑范围的远程投射,包括来自对侧半球的投射,以及植入部位附近的局部投射。这些输入包括谷氨酸能、胆碱能和gaba能神经元。移植肿瘤表现出对乙酰胆碱依赖的Ca2+反应,并且在胶质母细胞瘤细胞中敲低毒蕈碱乙酰胆碱受体M3可减少异种移植肿瘤的生长。总之,这些数据为脑肿瘤和神经网络之间复杂的相互作用提供了越来越多的证据。原始参考:Cell https://doi.org/10.1016/j.cell.2024.11.002 (2024)
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来源期刊
Nature neuroscience
Nature neuroscience 医学-神经科学
CiteScore
38.60
自引率
1.20%
发文量
212
审稿时长
1 months
期刊介绍: Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
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