Neuroethology of natural actions in freely moving monkeys

IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Science Pub Date : 2025-01-09 DOI:10.1126/science.adq6510
Francesca Lanzarini, Monica Maranesi, Elena Hilary Rondoni, Davide Albertini, Elena Ferretti, Marco Lanzilotto, Silvestro Micera, Alberto Mazzoni, Luca Bonini
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Abstract

The current understanding of primate natural action organization derives from laboratory experiments in restrained contexts (RCs) under the assumption that this knowledge generalizes to freely moving contexts (FMCs). In this work, we developed a neurobehavioral platform to enable wireless recording of the same premotor neurons in both RCs and FMCs. Neurons often encoded the same hand and mouth actions differently in RCs and FMCs. Furthermore, in FMCs, we identified cells that selectively encoded actions untestable during RCs and others that displayed mixed selectivity for multiple actions, which is compatible with an organization based on cortical motor synergies at different levels of complexity. Cross-context decoding demonstrated that neural activity in FMCs is richer and more generalizable than in RCs, which suggests that neuroethological approaches are better suited to unveil the neural bases of behavior.
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自由运动猴子自然行为的神经行为学
目前对灵长类动物自然行动组织的理解来自于在受限环境(RCs)中的实验室实验,并假设这种知识可以推广到自由运动环境(fmc)。在这项工作中,我们开发了一个神经行为平台,可以无线记录rc和fmc中相同的前运动神经元。在rc和fmc中,神经元通常对相同的手和嘴动作进行不同的编码。此外,在fmc中,我们发现了选择性编码在RCs中无法测试的动作的细胞,以及其他对多种动作表现出混合选择性的细胞,这与基于皮层运动协同作用的不同复杂程度的组织是相容的。跨上下文解码表明,fmc中的神经活动比rc中的更丰富,更普遍,这表明神经行为学方法更适合揭示行为的神经基础。
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来源期刊
Science
Science 综合性期刊-综合性期刊
CiteScore
61.10
自引率
0.90%
发文量
0
审稿时长
2.1 months
期刊介绍: Science is a leading outlet for scientific news, commentary, and cutting-edge research. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. Science’s authorship is global too, and its articles consistently rank among the world's most cited research. Science serves as a forum for discussion of important issues related to the advancement of science by publishing material on which a consensus has been reached as well as including the presentation of minority or conflicting points of view. Accordingly, all articles published in Science—including editorials, news and comment, and book reviews—are signed and reflect the individual views of the authors and not official points of view adopted by AAAS or the institutions with which the authors are affiliated. Science seeks to publish those papers that are most influential in their fields or across fields and that will significantly advance scientific understanding. Selected papers should present novel and broadly important data, syntheses, or concepts. They should merit recognition by the wider scientific community and general public provided by publication in Science, beyond that provided by specialty journals. Science welcomes submissions from all fields of science and from any source. The editors are committed to the prompt evaluation and publication of submitted papers while upholding high standards that support reproducibility of published research. Science is published weekly; selected papers are published online ahead of print.
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