The efficacy of porphyrin-loaded Au-functionalized polymeric nanodots alleviates acute kidney injury and nursing care via preferential renal accumulation and antioxidant capacity

IF 2.1 4区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Gold Bulletin Pub Date : 2025-01-09 DOI:10.1007/s13404-024-00355-5

Yingbing Kang, Jianzhong Zhang

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Abstract

Acute kidney injury (AKI) is a critical condition characterized by a rapid deterioration in kidney function, frequently resulting in severe complications and elevated mortality rates. Recent advancements in nanomedicine have introduced porphyrin-loaded gold (Au) functionalized polymeric nanodots (P-APNDs) as a promising therapeutic approach for AKI. The formation of P-APNDs was confirmed by analyzing physiochemical parameters such as FTIR, XRD, and TEM which revealed their spherical shape with a smaller size of 10 nm. The P-APND exhibits significant efficacy in alleviating AKI due to its preferential renal accumulation and potent antioxidant capacity. P-APND exhibited exceptional antioxidant properties in effectively scavenging various toxic free radicals, thereby providing efficient cellular protection against oxidative stresses in vitro at HEK 293 cell lines and found that P-APND was effective in treating cisplatin (Cs) induced cell lines. The in vivo analysis was carried out in a Cs-induced mice model. The accumulation of the drug in the kidney for a prolonged time shows the efficiency of the P-APND. The decreased serum creatinine levels and blood urea nitrogen confirm the improvement of kidney injury after the treatment with P-APND. Combining this therapy with comprehensive nursing care could mark a significant advancement in AKI management.

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卟啉负载的金功能化聚合物纳米点通过肾脏优先积累和抗氧化能力减轻急性肾损伤和护理

急性肾损伤（AKI）是一种以肾功能迅速恶化为特征的危重疾病，常导致严重并发症和死亡率升高。在纳米医学的最新进展中，载卟啉金功能化聚合物纳米点（P-APNDs）作为一种很有前景的治疗AKI的方法。通过FTIR、XRD、TEM等理化参数分析证实了p - apnd的形成，发现其粒径较小，为10 nm，呈球形。P-APND由于其优先的肾脏蓄积和强大的抗氧化能力，在缓解AKI方面表现出显著的疗效。在体外实验中，P-APND能有效清除多种有毒自由基，从而对HEK 293细胞系提供有效的细胞氧化应激保护，并发现P-APND对顺铂（Cs）诱导的细胞系有有效的治疗作用。采用cs诱导小鼠模型进行体内分析。药物在肾脏中积累较长时间表明P-APND的有效性。血清肌酐和尿素氮水平的降低证实了P-APND治疗后肾损伤的改善。将此疗法与综合护理相结合可以标志着AKI管理的重大进步。

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来源期刊

Gold Bulletin Chemistry-Inorganic Chemistry

CiteScore

3.70

自引率

4.50%

发文量

期刊介绍： Gold Bulletin is the premier international peer reviewed journal on the latest science, technology and applications of gold. It includes papers on the latest research advances, state-of-the-art reviews, conference reports, book reviews and highlights of patents and scientific literature. Gold Bulletin does not publish manuscripts covering the snthesis of Gold nanoparticles in the presence of plant extracts or other nature-derived extracts. Gold Bulletin has been published over 40 years as a multidisciplinary journal read by chemists, physicists, engineers, metallurgists, materials scientists, biotechnologists, surface scientists, and nanotechnologists amongst others, both within industry and academia. Gold Bulletin is published in Association with the World Gold Council.