Tenascin-C promotes bone regeneration via inflammatory macrophages

IF 13.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Death and Differentiation Pub Date : 2025-01-10 DOI:10.1038/s41418-024-01429-9

Qian Ren, Wenhui Xing, Bo Jiang, Heng Feng, Xuye Hu, Jinlong Suo, Lijun Wang, Weiguo Zou

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Abstract

During the early stage of tissue injury, macrophages play important roles in the activation of stem cells for further regeneration. However, the regulation of macrophages during bone regeneration remains unclear. Here, the extracellular matrix (ECM) tenascin-C (TNC) is found to express in the periosteum and recruit inflammatory macrophages. TNC-deficiency in the periosteum delays bone repair. Transplantation of macrophages derived from injured periosteum is able to rescue the decreased skeletal stem cells and impaired bone regeneration caused by TNC deficiency. The cell communication analysis identifies ITGA7 as a TNC receptor contributing to the recruitment of inflammatory macrophages. TNC expression declines in aged mice and the exogenous delivery of TNC significantly promotes bone regeneration after aging through the recruitment of macrophages. Taken together, this study reveals the regulation of macrophage recruitment and its function in the activation of skeletal stem cells after bone injury, providing a strategy to accelerate bone regeneration by TNC delivery.

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Tenascin-C通过炎性巨噬细胞促进骨再生

在组织损伤早期，巨噬细胞在激活干细胞进一步再生中发挥重要作用。然而，巨噬细胞在骨再生过程中的调控作用尚不清楚。在这里，发现细胞外基质（ECM） tenascin-C （TNC）在骨膜中表达并招募炎性巨噬细胞。骨膜tnc缺乏会延迟骨修复。移植来自损伤骨膜的巨噬细胞可以挽救因TNC缺乏而导致的骨骼干细胞减少和骨再生受损。细胞通讯分析确定ITGA7是一种TNC受体，有助于炎性巨噬细胞的募集。衰老小鼠TNC表达下降，外源性TNC通过募集巨噬细胞显著促进衰老后骨再生。综上所述，本研究揭示了骨损伤后巨噬细胞募集的调控及其在骨骼干细胞激活中的功能，为通过TNC输送加速骨再生提供了一种策略。

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来源期刊

Cell Death and Differentiation 生物-生化与分子生物学

CiteScore

24.70

自引率

1.60%

发文量

181

审稿时长

3 months

期刊介绍： Mission, vision and values of Cell Death & Differentiation: To devote itself to scientific excellence in the field of cell biology, molecular biology, and biochemistry of cell death and disease. To provide a unified forum for scientists and clinical researchers It is committed to the rapid publication of high quality original papers relating to these subjects, together with topical, usually solicited, reviews, meeting reports, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.