Effects of Self-Perceptions of Cognitive Decline on Cognitive Assessment Outcomes in the Women’s Alzheimer’s Movement Prevention Center at Cleveland Clinic

IF 13 1区 医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-01-09 DOI:10.1002/alz.092611
Nikki L Kaplan, Emily Post, Taylor F Levine, Jessica ZK Caldwell
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Abstract

Background

The Women’s Alzheimer’s Movement Prevention Center (WAMPC) at Cleveland Clinic evaluates women’s risk factors for developing Alzheimer’s disease and provides personalized recommendations for reducing risk. Previous research has established that up to 40% of Alzheimer’s disease (AD) cases might be prevented when modifiable risk factors are addressed. To better understand individual risk profiles, a wealth of information is collected, including self-reported health conditions (both personal and familial), lifestyle factors (e.g. alcohol and tobacco use, exercise, social support), a brief cognitive test battery, and blood tests. WAMPC takes a holistic approach in helping women combat modifiable risks for AD.

Method

207 women from the WAMPC who consented to have their clinical data used for research purposes were assessed (mean age = 53.39, SD = 9.53). Requirements for participation include normal cognition and family history of Alzheimer’s disease. Patients completed the Mini Mental State Exam (MMSE), selected tests from the NIH Toolbox (Oral-Symbol Digit, Processing Speed, Picture Vocabulary, Card Sort, and Flanker), Controlled Oral Word Association Test-FAS (COWAT: FAS, Animal Naming), and the Trail Making Test Part B. Patients also completed the Subjective Cognitive Decline Questionnaire (SCDQ), a self-report assessment of perceived cognitive changes. We transformed SCDQ total scores into cohort-based z-scores to create three SCDQ groups (“fewer cognitive concerns” = bottom third, “average cognitive concerns” = middle third, and “above average cognitive concerns” = top third. We evaluated the relationship between performance on cognitive tests and women’s perceived cognitive decline on SCDQ. We ran 9 individual ANCOVAs, one for each cognitive test, using education and age as covariates.

Result

Of the tests evaluated, the SCDQ significantly predicted scores on Animal Naming (F(2,190) = 3.602, p = .029) and NIH Toolbox Card Sorting (F(2,190) = 3.597, p = .029). No other tests demonstrated significant relationships with self-perceptions of cognitive decline per the SCDQ.

Conclusion

Perceived cognitive decline in daily life predicted concurrent poorer performance on selected tests of language and executive function, in women who are cognitively normal, yet at increased risk for AD based on family history. Further work is needed to understand whether subjective cognitive concerns may represent risk for cognitive decline in this cohort of women with family history of AD.

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克利夫兰诊所女性阿尔茨海默病运动预防中心认知衰退自我知觉对认知评估结果的影响
克利夫兰诊所的女性阿尔茨海默病运动预防中心(WAMPC)评估女性患阿尔茨海默病的危险因素,并提供降低风险的个性化建议。先前的研究已经证实,当可改变的风险因素得到解决时,高达40%的阿尔茨海默病(AD)病例是可以预防的。为了更好地了解个人风险概况,收集了大量信息,包括自我报告的健康状况(个人和家庭)、生活方式因素(如酒精和烟草使用、运动、社会支持)、简短的认知测试和血液测试。WAMPC采用整体方法帮助妇女对抗AD的可变风险。方法对207名同意将临床资料用于研究目的的WAMPC女性进行评估(平均年龄= 53.39,SD = 9.53)。参与条件包括正常认知和阿尔茨海默病家族史。患者完成了迷你精神状态测试(MMSE),从NIH工具箱中选择的测试(口头符号数字,处理速度,图片词汇,卡片分类和侧卫),控制口头单词联想测试- FAS (COWAT: FAS,动物命名)和轨迹测试b部分。患者还完成了主观认知衰退问卷(SCDQ),这是一项对感知认知变化的自我报告评估。我们将SCDQ总分转换为基于队列的z分数,创建了三个SCDQ组(“较少认知关注”=后三分之一,“平均认知关注”=中三分之一,“高于平均认知关注”=前三分之一)。我们评估了认知测试的表现与女性在SCDQ上认知能力下降之间的关系。我们运行了9个单独的ANCOVAs,每个认知测试一个,使用教育和年龄作为协变量。结果SCDQ显著预测动物命名(F(2190) = 3.602, p = 0.029)和NIH工具箱卡片分类(F(2190) = 3.597, p = 0.029)。根据SCDQ,没有其他测试显示与认知能力下降的自我感知有显著关系。结论:在认知正常但家族史上AD风险增加的女性中,日常生活认知能力下降预示着在语言和执行功能的选择测试中同时表现较差。在这组有AD家族史的女性中,主观认知问题是否代表认知能力下降的风险还需要进一步的研究。
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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