Key Facets for the Elimination of Vector-Borne Diseases Filariasis, Leishmaniasis, and Malaria.

IF 3.8 2区 医学 Q2 CHEMISTRY, MEDICINAL ACS Infectious Diseases Pub Date : 2025-02-14 Epub Date: 2025-01-09 DOI:10.1021/acsinfecdis.4c00431
Rini Chaturvedi, Amit Sharma
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Abstract

Vector-borne diseases are caused by microbes transmitted to humans through vectors such as mosquitoes, ticks, flies, and other arthropods. Three vector-borne diseases, filariasis, leishmaniasis, and malaria, are significant parasitic diseases which are responsible for long-term morbidity and mortality affecting millions globally. These diseases exhibit several similarities in transmission, health impacts, and the challenges faced in their control and prevention. By identifying these commonalities and fostering cooperation among disease control programs, we can strengthen our efforts to combat them and hence enhance the health of at-risk populations. This review summarizes the key points associated with the epidemiology, transmission dynamics, and therapeutic regimes for each disease, presenting a holistic overview of these three eliminable diseases.

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消除媒介传播疾病的关键方面:丝虫病、利什曼病和疟疾。
媒介传播疾病是由微生物通过蚊子、蜱虫、苍蝇和其他节肢动物等媒介传播给人类引起的。丝虫病、利什曼病和疟疾这三种病媒传播疾病是严重的寄生虫病,造成全球数百万人长期发病和死亡。这些疾病在传播、健康影响以及在控制和预防方面面临的挑战方面表现出若干相似之处。通过确定这些共性并促进疾病控制规划之间的合作,我们可以加强努力,与它们作斗争,从而提高高危人群的健康水平。本文综述了与每种疾病的流行病学、传播动力学和治疗方案相关的要点,对这三种可消除疾病进行了全面概述。
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来源期刊
ACS Infectious Diseases
ACS Infectious Diseases CHEMISTRY, MEDICINALINFECTIOUS DISEASES&nb-INFECTIOUS DISEASES
CiteScore
9.70
自引率
3.80%
发文量
213
期刊介绍: ACS Infectious Diseases will be the first journal to highlight chemistry and its role in this multidisciplinary and collaborative research area. The journal will cover a diverse array of topics including, but not limited to: * Discovery and development of new antimicrobial agents — identified through target- or phenotypic-based approaches as well as compounds that induce synergy with antimicrobials. * Characterization and validation of drug target or pathways — use of single target and genome-wide knockdown and knockouts, biochemical studies, structural biology, new technologies to facilitate characterization and prioritization of potential drug targets. * Mechanism of drug resistance — fundamental research that advances our understanding of resistance; strategies to prevent resistance. * Mechanisms of action — use of genetic, metabolomic, and activity- and affinity-based protein profiling to elucidate the mechanism of action of clinical and experimental antimicrobial agents. * Host-pathogen interactions — tools for studying host-pathogen interactions, cellular biochemistry of hosts and pathogens, and molecular interactions of pathogens with host microbiota. * Small molecule vaccine adjuvants for infectious disease. * Viral and bacterial biochemistry and molecular biology.
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