Yuchen Zeng (曾雨晨) , Wei Lv (吕伟) , Huiying Tao (陶荟颖) , Conghui Li (李聪慧) , Shiqi Jiang (蒋世琪) , Yuan Liang (梁媛) , Chen Chen (陈晨) , Tianxi Yu (于天熙) , Yue Li (李悦) , Shuang Wu (吴双) , Xin Cui (崔鑫) , Ning Liang (梁宁) , Ping Wang (王平) , Huixin Xu (许荟馨) , Jingjing Dong (董晶晶) , Huajing Teng (滕花景) , Ke Chen (谌科) , Kai Mu (穆锴) , Tianda Fan (范天达) , Xiaoping Cen (岑萧萍) , Peng Han (韩鹏)
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引用次数: 0
Abstract
Chromothripsis, a hallmark of cancer, is characterized by extensive and localized DNA rearrangements involving one or a few chromosomes. However, its genome-wide frequency and characteristics in urothelial carcinoma (UC) remain largely unknown. Here, by analyzing single-regional and multi-regional whole-genome sequencing (WGS), we present the chromothripsis blueprint in 488 UC patients. Chromothripsis events exhibit significant intertumoral heterogeneity, being detected in 41% of UC patients, with an increase from 30% in non-muscle-invasive disease (Ta/1) to 53% in muscle-invasive disease (T2-4). The presence of chromothripsis correlates with an unstable cancer genome and poor clinical outcomes. Analysis of multi-regional WGS data from 52 patients revealed pronounced intratumoral heterogeneity with chromothripsis events detectable only in specific tumor regions rather than uniformly across all areas. Chromothripsis events evolve under positive selection and contribute to tumor dissemination. This study presents a comprehensive genome-wide chromothripsis landscape in UC, highlighting the significance of chromothripsis in UC development.
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