{"title":"A Novel Hollow Core Antiresonant Fiber-Based Biosensor for Blood Component Detection in the THz Regime.","authors":"Maharaja Balaji, Sathiyan Samikannu","doi":"10.1088/2057-1976/ada88a","DOIUrl":null,"url":null,"abstract":"<p><p>This article proposes a novel biosensor based on a five-semi-circular cladding tube hollow core antiresonant fiber (HC-ARF) with a frequency range of 0.5-2.8 THz, using Zeonex as the background material. The HC-ARF biosensor analyses various blood components, namely water, plasma, white blood cells (WBC), hemoglobin (HB), and red blood cells (RBC). We utilized COMSOL Multiphysics to perform the numerical analysis of the sensor model. For water, plasma, WBC, HB, and RBC, the proposed HC-ARF
biosensor exhibits the highest sensitivity levels of 99.50%, 99.58%, 99.43%, 99.58% and 99.46%, respectively. Furthermore, it demonstrates confinement loss (CL) and effective material loss (EML) of 1.3 ×10-3 dBcm-1 and 5.3 ×10-5 dBcm-1, respectively.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Physics & Engineering Express","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/2057-1976/ada88a","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
This article proposes a novel biosensor based on a five-semi-circular cladding tube hollow core antiresonant fiber (HC-ARF) with a frequency range of 0.5-2.8 THz, using Zeonex as the background material. The HC-ARF biosensor analyses various blood components, namely water, plasma, white blood cells (WBC), hemoglobin (HB), and red blood cells (RBC). We utilized COMSOL Multiphysics to perform the numerical analysis of the sensor model. For water, plasma, WBC, HB, and RBC, the proposed HC-ARF
biosensor exhibits the highest sensitivity levels of 99.50%, 99.58%, 99.43%, 99.58% and 99.46%, respectively. Furthermore, it demonstrates confinement loss (CL) and effective material loss (EML) of 1.3 ×10-3 dBcm-1 and 5.3 ×10-5 dBcm-1, respectively.
期刊介绍：
BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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