Brain-Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta-Analysis.

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2025-01-01 DOI:10.1002/brb3.70266

Fatemeh Hasani, Mahdi Masrour, Sina Khamaki, Kimia Jazi, Erfan Ghoodjani, Antonio L Teixeira

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Abstract

Background: This systematic review and meta-analysis evaluates peripheral and CNS BDNF levels in glioma patients.

Methods: Following PRISMA guidelines, we systematically searched databases for studies measuring BDNF in glioma patients and controls. After screening and data extraction, we conducted quality assessment, meta-analysis, and meta-regression.

Results: Eight studies were included. Meta-analysis showed significantly reduced plasma BDNF levels in glioma patients versus controls (SMD: -1.0026; 95% CI: [-1.5284, -0.4769], p = 0.0002). High-grade gliomas had lower plasma BDNF (p = 0.0288). Tissue BDNF levels were higher in glioma patients (SMD: 1.9513; 95% CI: [0.7365, 3.1661], p = 0.0016) and correlated with tumor grade (p = 0.0122). Plasma BDNF levels negatively correlated with patient age (p = 0.0244) and positively with female percentage (p = 0.0007).

Conclusion: BDNF is a promising biomarker in glioma, showing significant changes in plasma and tissue levels correlating with tumor grade, patient age, and gender.

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脑源性神经营养因子（BDNF）作为脑胶质瘤的潜在生物标志物：系统综述和荟萃分析

背景：本系统综述和荟萃分析评估了胶质瘤患者外周血和中枢神经系统BDNF水平。方法：遵循PRISMA指南，我们系统地检索数据库，以测量胶质瘤患者和对照组的BDNF。在筛选和数据提取后，我们进行了质量评估、meta分析和meta回归。结果：纳入8项研究。荟萃分析显示，与对照组相比，胶质瘤患者血浆BDNF水平显著降低(SMD: -1.0026；95% CI: [-1.5284, -0.4769], p = 0.0002)。高级别胶质瘤的血浆BDNF较低（p = 0.0288）。胶质瘤患者组织BDNF水平较高(SMD: 1.9513；95% CI: [0.7365, 3.1661], p = 0.0016)，且与肿瘤分级相关（p = 0.0122）。血浆BDNF水平与患者年龄呈负相关（p = 0.0244），与女性比例呈正相关（p = 0.0007）。结论：BDNF是一种很有前景的神经胶质瘤生物标志物，其血浆和组织水平与肿瘤分级、患者年龄和性别相关。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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