Antemortem diagnostic tests and treatment outcomes using ivermectin in 13 cases of presumptive feline neurocuterebriasis.

IF 0.9 4区农林科学 Q3 VETERINARY SCIENCES Canadian Veterinary Journal-revue Veterinaire Canadienne Pub Date : 2025-01-01

Xin Yu Wei Chen, Fiona M K James

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Abstract

Background: Limited reports exist on the antemortem presumptive diagnosis and treatment of feline neurocuterebriasis. A 3-day treatment protocol reported for 3 cats had no adverse effects. This protocol comprised ivermectin (0.4 mg/kg), diphenhydramine (4 mg/kg), and dexamethasone (0.1 mg/kg) given q24h.

Objective: To describe the treatment outcomes for cats that received the 3-day ivermectin protocol and antemortem diagnostic methods used before.

Animals and procedure: Medical records from a single veterinary referral centre were searched to identify cats treated with the 3-day protocol. Variables extracted included signalment, season, history, neurological examination findings, and advanced diagnostic tests, as well as outcomes based on follow-up.

Results: Thirteen cats were diagnosed based on advanced imaging. Ten of 13 also underwent cerebrospinal fluid analysis. Other diagnostic factors included season (July through September), signalment (young to middle-aged), lifestyle (outdoor access), history (7/13 cats showed upper respiratory signs preceding neurological deficits), and clinical signs (central neurological deficits). After being treated with the 3-day ivermectin protocol, 10/13 cats improved. Three cats were euthanized after showing worsening clinical signs.

Conclusion and clinical relevance: Outcomes using the 3-day ivermectin protocol appeared favorable. This provided insight about a treatment option for a periodic cause of feline encephalomyelopathy that has potential for deployment in first-opinion practice.

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使用伊维菌素治疗13例猫神经异体病的死前诊断试验和治疗结果

背景：关于猫神经毛囊炎的死前推定诊断和治疗的报道有限。据报道，3天的治疗方案对3只猫没有不良反应。该方案包括伊维菌素（0.4 mg/kg）、苯海拉明（4 mg/kg）和地塞米松（0.1 mg/kg），每24小时给药。目的：描述接受3天伊维菌素治疗方案的猫的治疗结果和之前使用的死前诊断方法。动物和程序：检索来自单一兽医转诊中心的医疗记录，以确定接受3天方案治疗的猫。提取的变量包括信号、季节、病史、神经学检查结果和高级诊断测试，以及基于随访的结果。结果：13只猫通过高级影像学诊断。13人中有10人还接受了脑脊液分析。其他诊断因素包括季节（7月至9月）、信号（青年至中年）、生活方式（户外活动）、病史（7/13只猫在神经功能障碍前出现上呼吸道症状）和临床症状（中枢神经功能障碍）。在接受3天伊维菌素治疗后，10/13只猫得到改善。三只猫在出现恶化的临床症状后被安乐死。结论和临床意义：使用3天伊维菌素方案的结果是有利的。这为猫脑脊髓病周期性病因的治疗方案提供了见解，该治疗方案具有在第一意见实践中部署的潜力。

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来源期刊

Canadian Veterinary Journal-revue Veterinaire Canadienne 农林科学-兽医学

CiteScore

1.20

自引率

10.00%

发文量

177

审稿时长

12-24 weeks

期刊介绍： The Canadian Veterinary Journal (CVJ) provides a forum for the discussion of all matters relevant to the veterinary profession. The mission of the Journal is to educate by informing readers of progress in clinical veterinary medicine, clinical veterinary research, and related fields of endeavor. The key objective of The CVJ is to promote the art and science of veterinary medicine and the betterment of animal health. A report suggesting that animals have been unnecessarily subjected to adverse, stressful, or harsh conditions or treatments will not be processed for publication. Experimental studies using animals will only be considered for publication if the studies have been approved by an institutional animal care committee, or equivalent, and the guidelines of the Canadian Council on Animal Care, or equivalent, have been followed by the author(s).