FAP-Targeted SPECT/CT and PET/CT Imaging for Breast Cancer Patients.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2025-03-01 Epub Date: 2025-01-09 DOI:10.1097/RLU.0000000000005617

Jeremy McGale, Sakshi Khurana, Harrison Howell, Abanoub Nakhla, Tina Roa, Parth Doshi, Dorsa Shirini, Alice Huang, Phuong Duong, Philipp Backhaus, Matthew Liao, Harleen Kaur, Amelia McNiven Fontani, Isabella Hung, Neeta Pandit-Taskar, Uwe Haberkorn, Amit Gulati, Asmâa Naim, Mathieu Sinigaglia, Maria Bebawy, Antoine Girard, Romain-David Seban, Laurent Dercle

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Abstract

Abstract: Breast cancer presents a significant global health challenge, necessitating continued innovation in diagnostic and therapeutic approaches. Recent advances have led to the identification of cancer-associated fibroblasts, which are highly prevalent in breast cancers and express fibroblast activation proteins (FAPs), as critical targets. FAP-specific radiotracers, when used with PET/CT and SPECT/CT, have significant potential for improving early breast cancer detection, staging, treatment response monitoring, and therapeutic intervention. This review provides insight into FAP-targeted molecular imaging, exploring advanced techniques for protein status assessment, development of early-phase targeted therapies, and other emerging applications. The advent of FAP-targeted imaging stands to significantly enhance personalized oncologic care, leading to improved breast cancer management and overall patient outcomes.

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乳腺癌患者fap靶向SPECT/CT和PET/CT成像研究。

摘要：乳腺癌是一项重大的全球健康挑战，需要在诊断和治疗方法上不断创新。最近的进展已经导致癌症相关成纤维细胞的鉴定，这些成纤维细胞在乳腺癌中非常普遍，并表达成纤维细胞激活蛋白（FAPs），作为关键靶点。当与PET/CT和SPECT/CT一起使用时，fap特异性放射性示踪剂具有显著的改善早期乳腺癌检测、分期、治疗反应监测和治疗干预的潜力。本文综述了fap靶向分子成像，探索蛋白质状态评估的先进技术，早期靶向治疗的发展以及其他新兴应用。fap靶向成像的出现将显著增强个性化的肿瘤护理，从而改善乳腺癌的管理和患者的整体预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.