Therapeutic potential of adipose-derived stem cells for diabetic foot ulcers: a systematic review and meta-analysis.

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Diabetology & Metabolic Syndrome Pub Date : 2025-01-07 DOI:10.1186/s13098-024-01523-5

Mohamed A Abu Elainein, Mohamad Mahmoud Whdan, Mahmoud Samir, Nada G Hamam, Mohamed Mansour, Mohamed Abdel Mohsen Mohamed, Mahmoud Mostafa Snosy, Mahmoud Ayman Othman, Ahmed Sayed Sobieh, Mahmoud Gamal Saad, Mohamed A Labna, Salma Allam

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Abstract

Background: As the global prevalence of diabetes mellitus increases, the incidence of non-healing wounds in diabetic patients is expected to rise significantly, according to the International Diabetes Federation (IDF), around 537 million adults currently suffer from diabetes mellitus worldwide and 20% to 30% of individuals with diabetes are hospitalized due to diabetic foot ulcers. Conventional treatments such as traditional dressings often fall short in ensuring satisfactory wound healing, this Meta-analysis investigates the therapeutic potential of Adipose-derived Stem Cells (ADSCs) as a promising strategy for addressing this challenge.

Aims: To Assess the Therapeutic Potential of Adipose-Derived Stem Cells for Managing Diabetic Foot Ulcers compared to conventional lines of treatments.

Methods: The PubMed, SCOPUS, Web of Science Core Collection, Cochrane Library, and ClinicalTrials.gov. databases were searched from January 2000 and December 2023, articles were primarily evaluated regarding their titles and abstracts, then full-text screening was assessed against the inclusion and exclusion criteria by utilizing Rayyan software. The Cochrane risk of bias (RoB 2) assessment tool was used to identify the risk of bias in our included studies. A statistical analysis was performed using Review Manager (RevMan) Version 5 software. Dichotomous data was subjected to risk ratio analysis, while continuous data underwent Mean Difference (MD) evaluation, all was reported with 95% confidence intervals, P value is considered statistically significant if less than 0.05.

Results: Regarding the total healing state, five studies reported that more participants healed completely at the end of the follow-up period in the ADSCs group (Risk ratio = 1.56, 95% CI [1.32, 1.86], P < 0.00001), for the healing rate the overall effect estimate favors the ADSCs group (pooled effect estimate = 1.84, 95% CI [1.51, 2.89], P < 0.00001), and regarding the healing time the pooled mean difference of the studies demonstrated that the ADSCs group required fewer days to heal than the standard care group. (pooled mean difference = -19.33, 95% CI [-37.36, -1.29], P = 0.04).

Conclusion: ADSCs provide favorable healing results and safety compared to standard care for diabetic foot ulcers.

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脂肪来源干细胞治疗糖尿病足溃疡的潜力：一项系统综述和荟萃分析。

背景：根据国际糖尿病联合会（IDF）的数据，随着全球糖尿病患病率的增加，糖尿病患者伤口不愈合的发生率预计将显著上升，目前全球约有5.37亿成年人患有糖尿病，20%至30%的糖尿病患者因糖尿病足溃疡住院。传统的治疗方法，如传统敷料，往往不能确保令人满意的伤口愈合，本荟萃分析调查了脂肪来源干细胞（ADSCs）作为解决这一挑战的有希望的策略的治疗潜力。目的：评估脂肪来源干细胞治疗糖尿病足溃疡的治疗潜力，并与传统治疗方法进行比较。方法：PubMed， SCOPUS, Web of Science Core Collection, Cochrane Library, ClinicalTrials.gov。检索检索自2000年1月至2023年12月的文献数据库，首先对文章的标题和摘要进行评价，然后利用Rayyan软件进行全文筛选，根据纳入标准和排除标准进行筛选。我们使用Cochrane偏倚风险（RoB 2）评估工具来确定纳入研究的偏倚风险。使用Review Manager (RevMan) Version 5软件进行统计分析。二分类资料进行风险比分析，连续资料进行Mean Difference （MD）评价，均以95%置信区间报道，P值小于0.05认为有统计学意义。结果：在总愈合状态方面，5项研究报道，在随访结束时，ADSCs组有更多的参与者完全愈合（风险比= 1.56,95% CI [1.32, 1.86]， P）。结论：与标准护理相比，ADSCs对糖尿病足溃疡提供了良好的愈合效果和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.