Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases.

IF 4.8 3区医学 Q2 CELL BIOLOGY Inflammation Research Pub Date : 2025-01-07 DOI:10.1007/s00011-024-01969-3

Xinyue Zhou, Yajie Wu, Yingqiu Song, Bing Wang, Yikang Cai, Chenggui Miao

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Abstract

Objective: Arthritis is a class of diseases, characterized by joint and surrounding inflammation, accompanied by joint swelling, pain, dysfunction. According to different factors, arthritis can be divided into osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and so on. N6-methyladenosine (m6A) is the most common internal modification of eukaryotic mRNA and is involved in splicing, stabilization, output and degradation of RNA metabolism. This review systematically summarized current insights into the mechanism of m6A in arthritis.

Methods: The studies related to the involvement of m6A in the pathogenesis of arthritis reported in PubMed, Google scholar, and other open source literatures were investigated to evaluate the important roles of m6A in arhtritis, and the clinical relevances.

Results and conclusions: M6A methylation regulators play the roles of writers, erasers, and readers, are crucial for regulating gene expression, and play important roles in many biological processes such as virus replication and cell differentiation. In addition, more and more studies have shown that m6A is closely related to the development of arthritis. As a new therapeutic target for arthritis, m6A has a wide influence on the pathological mechanism of arthritis. However, further research is needed to determine how m6A affects arthritis pathology and its use in target therapy and diagnosis.

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n6 -甲基腺苷在关节炎疾病中的作用机制和治疗见解。

目的：关节炎是一类以关节及周围炎症为特征，伴有关节肿胀、疼痛、功能障碍的疾病。根据不同的因素，关节炎可分为骨关节炎、类风湿关节炎、强直性脊柱炎等。n6 -甲基腺苷（m6A）是真核生物mRNA最常见的内部修饰，参与RNA代谢的剪接、稳定、输出和降解。这篇综述系统地总结了m6A在关节炎中的作用机制。方法：通过PubMed、谷歌scholar等开源文献中有关m6A参与关节炎发病机制的相关研究，评价m6A在关节炎中的重要作用及其临床意义。结果与结论：M6A甲基化调控因子具有书写器、擦除器和读取器的功能，在调控基因表达中起着至关重要的作用，在病毒复制和细胞分化等许多生物学过程中发挥着重要作用。此外，越来越多的研究表明m6A与关节炎的发生发展密切相关。m6A作为一种新的关节炎治疗靶点，对关节炎的病理机制有广泛的影响。然而，m6A如何影响关节炎病理及其在靶向治疗和诊断中的应用还需要进一步的研究。

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来源期刊

Inflammation Research 医学-免疫学

CiteScore

9.90

自引率

1.50%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.