Jing-Yu Zhang, Yi-Nuo Shi, Sheng Dong, Chen Ji, Yang Yu, Jiu-Zhi Yuan, Chong-Ning Lv, Jin-Cai Lu
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引用次数: 0
Abstract
A series of C21 steroidal glycosides were isolated from the roots and rhizomes of Vincetoxicum atratum (Bunge) C. Morren et Decne., including a new compound, cynatroside B2 (1), and seven known compounds (2-8). Their structures were identified by comprehensive spectroscopic analyses, including NMR and HR-ESI-MS spectral data. The isolated steroids were evaluated for their anti-inflammatory activity against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compound 1 displayed a significant inhibitory effect on NO, TNF-α and IL-1β.
从白花长春花（Vincetoxicum atratum (Bunge) C. Morren et Decne）的根和根茎中分离到一系列C21甾体苷。，包括一个新的化合物，cynatroside B2(1)和七个已知的化合物（2-8）。通过NMR和HR-ESI-MS光谱数据对其结构进行了鉴定。研究了分离的类固醇对脂多糖诱导的小鼠巨噬细胞RAW264.7细胞的抗炎活性。化合物1对NO、TNF-α、IL-1β均有明显抑制作用。
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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