Meta-analysis and Mendelian randomization study on the association between exposure to chlorinated disinfection byproducts and preterm birth risk.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2025-01-09 DOI:10.1038/s41372-024-02195-9

Changxia Cheng, Yanling Pei, Guangyu Shan, Yutao Liu

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Abstract

Objective: This study aims to investigate the correlation between exposure to disinfection byproducts of chlorination and preterm birth (PTB) through evidence-based medicine Meta-analysis and Mendelian randomization (MR) analysis.

Study design: Meta-analysis was conducted on 17 studies involving 1,251,426 neonates, revealing a higher risk of PTB with exposure to total trihalomethanes (TTHMs) and chloroform. Mendelian randomization (MR) analysis confirmed a causal relationship between chlorides and PTB.

Results: TTHMs and chloroform were associated with increased PTB risk, while haloacetic acids showed no significant association. TTHMs were linked to small gestational age. Ethnicity and study design influenced heterogeneity.

Conclusions: Exposure to chlorination byproducts, particularly TTHMs and chloroform, poses a significant risk for PTB. MR analysis supports a causal relationship between chlorides and PTB, highlighting the importance of water disinfection byproduct control in preventing PTB.

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氯化消毒副产物暴露与早产风险关系的荟萃分析和孟德尔随机化研究。

目的：通过循证医学meta分析和孟德尔随机化（MR）分析，探讨氯化消毒副产物暴露与早产（PTB）的相关性。研究设计：对涉及1,251,426名新生儿的17项研究进行了荟萃分析，揭示了暴露于总三卤甲烷（TTHMs）和氯仿的PTB风险较高。孟德尔随机化（MR）分析证实了氯化物与肺结核之间的因果关系。结果：TTHMs和氯仿与PTB风险增加相关，而卤乙酸无显著相关性。tthm与胎龄小有关。种族和研究设计影响异质性。结论：暴露于氯化副产物，特别是TTHMs和氯仿，对肺结核有显著的风险。核磁共振分析支持氯化物与肺结核之间的因果关系，强调了水消毒副产物控制对预防肺结核的重要性。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.