J Rajaselvam, M R Basil Rose, U Elaya Perumal, P Vijayaraghavan
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引用次数: 0
Abstract
Lectins are naturally occurring agglutinins which are produced more from plants sources compared to animal sources. The present study aims to screen the potential applications of lectin isolated from the mangrove plant, Rhizophora mucronata Poir. This root agglutinin of R. mucronata showed highest HA titre with buffalo erythrocytes. The agglutinin activity was pH dependent, thermolabile, calcium dependent and sensitive to divalent EDTA chelators. The agglutinability was dominantly inhibited by simple sugars, glucose and melibiose. The agglutinin was partially purified by biospecific adsorption using formalinized buffalo erythrocytes yield 21.81 fold increase in activity. Purified R. mucronata root lectin (RmrL) showed cytotoxic activity against HeLa (Cervical cancer) cell lines (IC50 value-161.305 µg/ml) and also exhibited antimicrobial activity against multidrug resistant bacterial strains.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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