Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2025-01-08 DOI:10.1038/s41522-024-00639-w

Wenzheng Guan, Tian Zhou, Jiao Jiao, Liwen Xiao, Zhen Wang, Siyuan Liu, Fujie Yan, Fangqing Zhao, Xiuxia Wang

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Abstract

This study aims to evaluate differences in gut microbiota structures between infertile women undergoing frozen embryo transfer (FET) with gestational diabetes mellitus (GDM) and healthy controls (HCs), and to identify potential markers. We comprehensively enrolled 193 infertile women undergoing FET (discovery cohort: 38 HCs and 31 GDM; validation cohort: 85 HCs and 39 GDM). Gut microbial profiles of the discovery cohort were investigated during the pre-pregnancy (Pre), first trimester (T1), and second trimester (T2). The microbial community in the HCs group remained relatively stable throughout the pregnancy, while the microbial structure alteration occurred in the GDM group during T2. A model based on ten bacteria and ten metabolites simultaneously was used to predict the risk of GDM developing in the pre-pregnancy state with the ROC value of 0.712. Algorithms on the basis of marker species and biochemical parameters can be used as effective tools for GDM risk evaluation before pregnancy.

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冷冻胚胎移植合并妊娠期糖尿病的不孕妇女孕前微生物组特征。

本研究旨在评估冷冻胚胎移植（FET）合并妊娠期糖尿病（GDM）的不孕妇女与健康对照（hc）之间肠道微生物群结构的差异，并确定潜在的标志物。我们全面招募了193名接受FET治疗的不孕妇女(发现队列：38名hc和31名GDM；验证队列：85例hcc和39例GDM)。研究了发现队列在妊娠前（Pre）、妊娠早期（T1）和妊娠中期（T2）的肠道微生物谱。HCs组的微生物群落在整个妊娠期间保持相对稳定，而GDM组的微生物结构在T2期间发生改变。采用10种细菌和10种代谢物同时存在的模型预测妊娠前期GDM发生风险，ROC值为0.712。基于标记物种和生化参数的算法可作为孕前GDM风险评估的有效工具。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.