Effect of Glomerular Hyperfiltration on Incident Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus.

IF 7.1 1区医学 Q1 UROLOGY & NEPHROLOGY Clinical Journal of the American Society of Nephrology Pub Date : 2025-03-01 Epub Date: 2025-01-09 DOI:10.2215/CJN.0000000618

Seung Min Chung, Inha Jung, Da Young Lee, So Young Park, Ji Hee Yu, Jun Sung Moon, Ji A Seo, Kyung-Do Han, Nan Hee Kim

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肾小球高滤过对2型糖尿病患者心血管疾病的影响

背景：探讨肾小球高滤过（GHF）对2型糖尿病（T2DM）患者心血管疾病（CVD）风险的影响。方法：本回顾性队列研究从2015年至2016年韩国国民健康保险服务数据库中招募了1,952,053例2型糖尿病患者。根据年龄和性别特异性估计肾小球滤过率（eGFR）百分位数，将患者分为五组：95组（GHF）。突发心血管疾病（CVD）（心肌梗死[MI]、中风和心力衰竭住院[HF]）的患者随访至2022年12月。结果：CVD发生214111例（11%）。eGFR组的发病率分别为每1000人年36.1、20.8、18.3、18.7和19.3例。低滤过率（风险比[HR] = 1.56, 95%可信区间[CI] 1.53-1.59）和GHF （HR = 1.13, 95%可信区间[CI] 1.10-1.15）与经协变量调整后的eGFR 40-60百分位的心血管疾病风险相关，呈倒j型关系。GHF与较高的心肌梗死（HR = 1.06, 95% CI 1.01-1.11）和心衰（HR = 1.17, 95% CI 1.14-1.20）以及较高的卒中风险相关。在年龄、性别、肥胖、高血压和血脂异常亚组中，eGFR与CVD风险相关。GHF对CVD的影响可能在年轻患者中更大（HR = 1.30, 1.17和1.05）。结论：GHF与CVD相关，尤其是心肌梗死和心衰。在T2DM早期筛查GHF可能是有益的。

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来源期刊

Clinical Journal of the American Society of Nephrology 医学-泌尿学与肾脏学

CiteScore

12.20

自引率

3.10%

发文量

514

审稿时长

3-6 weeks

期刊介绍： The Clinical Journal of the American Society of Nephrology strives to establish itself as the foremost authority in communicating and influencing advances in clinical nephrology by (1) swiftly and effectively disseminating pivotal developments in clinical and translational research in nephrology, encompassing innovations in research methods and care delivery; (2) providing context for these advances in relation to future research directions and patient care; and (3) becoming a key voice on issues with potential implications for the clinical practice of nephrology, particularly within the United States. Original manuscript topics cover a range of areas, including Acid/Base and Electrolyte Disorders, Acute Kidney Injury and ICU Nephrology, Chronic Kidney Disease, Clinical Nephrology, Cystic Kidney Disease, Diabetes and the Kidney, Genetics, Geriatric and Palliative Nephrology, Glomerular and Tubulointerstitial Diseases, Hypertension, Maintenance Dialysis, Mineral Metabolism, Nephrolithiasis, and Transplantation.