Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic.

IF 4.5 3区医学 Q1 MICROBIOLOGY International Journal of Medical Microbiology Pub Date : 2025-01-03 DOI:10.1016/j.ijmm.2024.151644

Roman Chlibek, Jan Smetana, Kateřina Kybicová, Martina Malikova, Frederick J Angulo, Alexandra Loew-Baselli, Ye Tan, Aleš Ondřejíček, Gordon Brestrich, Andreas Pilz, Jennifer C Moïsi, James H Stark

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Abstract

Introduction: Lyme borreliosis (LB), an infection caused by Borrelia burgdorferi sensu lato (Bbsl), is the most common tick-borne disease in Europe. To further characterize the LB burden in the Czech Republic, we conducted a seroprevalence study and estimated the incidence of symptomatic Bbsl infections.

Methods: Anti-Bbsl IgM and IgG antibodies were detected in sera collected from the adult population in 2011 -2012 by enzyme-linked immunosorbent assay and immunoblot tests at the National Reference Laboratory. The incidence of symptomatic Bbsl infections was estimated from the seroprevalence results and the symptomatic proportion and duration of persistence of anti-Bbsl IgG antibodies in Bbsl-infected individuals. Surveillance under-detection of symptomatic Bbsl infections was estimated by comparing surveillance-reported and seroprevalence-based incidence.

Results: Samples from 1996 adults were tested; the median age (range) was 45 (18 -87) years; 1037 (52.0 %) were female. The prevalence (with 95 % confidence interval) of anti-Bbsl IgG, and IgM and/or IgG (IgM/IgG) antibodies was 6.3 % (5.3 -7.5 %), and 9.5 % (8.3 -10.9 %), respectively. The IgM/IgG prevalence was 7.8 % (6.5 -9.2 %) in Bohemia and 15.3 % (12.2 -19.0 %) in Moravia. There were an estimated 30,563 (26,550 -34,962) symptomatic incident Bbsl infections in adults in the Czech Republic in 2012, for an incidence of 352.2 (306.0 -402.9) symptomatic Bbsl infections per 100,000 adults per year. There were an estimated 11 (10 -13) symptomatic Bbsl infections for each surveillance-reported LB case in the Czech Republic in 2012.

Conclusions: There is high incidence of symptomatic Bbsl infections in the Czech Republic, particularly in Moravia. Interventions are needed to address the substantial burden of LB in the Czech Republic.

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捷克共和国伯氏疏螺旋体感染流行情况。

莱姆伯氏疏螺旋体（LB）是一种由伯氏疏螺旋体引起的传染性疾病，是欧洲最常见的蜱传疾病。为了进一步表征捷克共和国的LB负担，我们进行了一项血清患病率研究，并估计了有症状的Bbsl感染的发生率。方法：在国家参考实验室采用酶联免疫吸附法和免疫印迹法检测2011年 -2012年成人血清中抗bbsl IgM和IgG抗体。根据血清流行率结果和血脊髓炎感染者血清抗血脊髓炎IgG抗体的症状性比例和持续时间估计血脊髓炎感染的症状性发生率。通过比较监测报告和基于血清患病率的发病率，估计监测未发现有症状的Bbsl感染。结果：对1996名成年人的样本进行了测试；中位年龄（范围）为45（18 -87）岁；女性1037例（52.0 %）。抗bbsl IgG、IgM和/或IgG （IgM/IgG）抗体的患病率（置信区间为95 %）分别为6.3 %（5.3 -7.5 %）和9.5 %（8.3 -10.9 %）。波希米亚IgM/IgG患病率为7.8 %(6.5 -9.2 %)，摩拉维亚为15.3 %（12.2 -19.0 %）。据估计，2012年捷克共和国成人有30,563例（26,550 -34,962例）有症状的Bbsl感染，每10万成年人每年有352.2例（306.0 -402.9）有症状的Bbsl感染。2012年，捷克共和国每一例监测报告的LB病例中估计有11例（10 -13）有症状的Bbsl感染。结论：在捷克共和国，特别是在摩拉维亚，有症状的Bbsl感染的发生率很高。需要采取干预措施，以解决捷克共和国LB的沉重负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Medical Microbiology 医学-病毒学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

45 days

期刊介绍： Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.