Evaluation of objective methods for analyzing ipsilateral motor evoked potentials in stroke survivors with chronic upper extremity motor impairment.

Abstract

Objective:Ipsilateral motor evoked potentials (iMEPs) are believed to represent cortically evoked excitability of uncrossed brainstem-mediated pathways. In the event of extensive injury to (crossed) corticospinal pathways, which can occur following a stroke, uncrossed ipsilateral pathways may serve as an alternate resource to support the recovery of the paretic limb. However, iMEPs, even in neurally intact people, can be small, infrequent, and noisy, so discerning them in stroke survivors is very challenging. This study aimed to investigate the inter-rater reliability of iMEP features (presence/absence, amplitude, area, onset, and offset) to evaluate the reliability of existing methods for objectively analyzing iMEPs in stroke survivors with chronic upper extremity motor impairment. Approach:Two investigators subjectively measured iMEP features from thirty-two stroke participants with chronic upper extremity motor impairment. Six objective methods based on standard deviation (SD) and mean consecutive differences (MCD) were used to measure the iMEP features from the same 32 participants. IMEP analysis used both trial-by-trial (individual signal) and average-signal analysis approaches. Inter-rater reliability of iMEP features and agreement between the subjective and objective methods were analyzed (percent agreement-PA and intraclass correlation coefficient-ICC). Main results:Inter-rater reliability was excellent for iMEP detection (PA> 85%), amplitude, and area (ICC> 0.9). Of the six objective methods we tested, the 1SD method was most appropriate for identifying and analyzing iMEP amplitude and area (ICC> 0.9) in both trial-by-trial and average signal analysis approaches. None of the objective methods were reliable for analyzing iMEP onset and offset. Results also support using the average-signal analysis approach over the trial-by-trial analysis approach, as it offers excellent reliability for iMEP analysis in stroke survivors with chronic upper extremity motor impairment. Significance:Findings from our study have relevance for understanding the role of ipsilateral pathways that typically survive unilateral severe white matter injury in people with stroke. .