{"title":"Selective Synthesis of 2-(Indol-3-Yl)Phenols via Iodine-Catalyzed C3-Arylation of Indoles with Cyclohexanones","authors":"Qi Yin, Xinlin Zhou, Chao Zhang, Shanping Chen, Yuxia Li, Guo-Jun Deng","doi":"10.1002/adsc.202401507","DOIUrl":null,"url":null,"abstract":"<p>An iodine-catalyzed C3-arylation of indoles with cyclohexanones to selectively synthesize 2-(indol-3-yl)phenols has been described. Mechanism studies indicate that the oxygen atom in 2-(indol-3-yl)phenols is originally from DMSO. This cascade involving dehydration condensation, selective oxygenation, dehydrogenation, and aromatization was achieved in one pot under transition-metal-free conditions.</p>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 7","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.202401507","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
An iodine-catalyzed C3-arylation of indoles with cyclohexanones to selectively synthesize 2-(indol-3-yl)phenols has been described. Mechanism studies indicate that the oxygen atom in 2-(indol-3-yl)phenols is originally from DMSO. This cascade involving dehydration condensation, selective oxygenation, dehydrogenation, and aromatization was achieved in one pot under transition-metal-free conditions.
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