Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system

IF 4.2 3区医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2025-01-13 DOI:10.1007/s10856-024-06857-0

S. F. Mirtaheri, S. N. Mousavi, Z. Abdi, E. Hosseini, M. S. Seyed Dorraji, F. Kabiri Esfahani, M. Gholami

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Abstract

Preserving fertility is important in men under radiation therapy because healthy cells are also affected by radiation. Supplementation with antioxidants is a controversial issue in this process. Designing a biocompatible delivery system containing hydrophobic antioxidants to release control may solve these disagreements. Herein, a bifunctional periodic mesoporous organosilica (PMO) was designed to load quercetin (Quer) and its application was studied on damaged cells induced by irradiation on the male reproductive system. Quercetin-loaded on PMO significantly improved the length and width of the testis after irradiation compared to the Quer, alone (p < 0.001 and p < 0.001, respectively). Sperm viability was significantly higher in the Quer-loaded on PMO than Quer, alone after irradiation (p < 0.001). Irradiation significantly decreased the sperm count (p = 0.01), however, Quer and Quer-loaded on PMO could not increase them to the normal ranges. Quer alone and loaded on PMO significantly reduced the sperm with abnormal morphology after irradiation (p < 0.001). Quer alone, and loaded on PMO significantly increased daily production of sperm after irradiation (p < 0.001). The number of apoptotic cells significantly increased after irradiation (p < 0.001). After irradiation, Quer loaded on PMO significantly decreased the apoptotic cells compared to the irradiated (p < 0.001) and Quer, alone groups (p < 0.001). The novel synthesized PMO containing Quer reduced the side effects of irradiation on the male reproductive system.

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槲皮素负载双功能介孔二氧化硅对辐照对男性生殖系统损伤的保护作用

对于接受放射治疗的男性来说，保持生育能力很重要，因为健康细胞也会受到辐射的影响。在这个过程中补充抗氧化剂是一个有争议的问题。设计一种含有疏水性抗氧化剂的生物相容性释放系统可以解决这些分歧。本文设计了一种双功能周期介孔有机硅（PMO）来负载槲皮素（Quer），并研究了其在辐照诱导的男性生殖系统损伤细胞中的应用。与单独使用Quer相比，PMO上负载槲皮素显著改善了照射后睾丸的长度和宽度（分别为p <； 0.001和p <； 0.001）。在PMO上装载Quer的精子活力明显高于单独照射后的Quer （p < 0.001）。辐照显著降低了精子数量（p = 0.01），而Quer和PMO上的Quer不能使精子数量增加到正常范围。单用Quer和PMO加载可显著减少辐照后形态异常的精子（p < 0.001）。单独使用Quer和加载PMO显著增加辐照后精子的日生成量（p < 0.001）。辐照后凋亡细胞数量显著增加（p < 0.001）。照射后，与照射组（p < 0.001）和单独照射组（p < 0.001）相比，Quer负载PMO显著减少了凋亡细胞。新型合成的含Quer的PMO减少了辐照对男性生殖系统的副作用。图形抽象

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.