Exploring the potential role of C-peptide in type 2 diabetes management

IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Diabetic Medicine Pub Date : 2025-01-11 DOI:10.1111/dme.15469
YeunYi Lin, Rory J. McCrimmon, Ewan R. Pearson
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Abstract

Type 2 diabetes (T2D) is a complex condition characterised by the interaction between insulin resistance and beta cell dysfunction. C-peptide, a key biomarker of endogenous insulin secretion, has a role in diagnosing type 1 diabetes (T1D). However, its utility in T2D has not been extensively studied. This review provides an overview of the progression of C-peptide levels over time in T2D and discuss its interpretation in clinical settings. We reviewed current evidence on the relationship between C-peptide levels and response to antidiabetic drugs, as well as the utility of C-peptide testing in T2D treatment strategies. We also reviewed available evidence for C-peptide in predicting future outcomes in T2D. In this review, we hoped to clarify the value of C-peptide testing in understanding and managing T2D and to highlight areas where further research is needed.

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探讨c肽在2型糖尿病治疗中的潜在作用。
2型糖尿病(T2D)是一种复杂的疾病,其特征是胰岛素抵抗和β细胞功能障碍之间的相互作用。c肽是内源性胰岛素分泌的关键生物标志物,在1型糖尿病(T1D)诊断中具有重要作用。然而,其在T2D中的应用尚未得到广泛研究。这篇综述概述了T2D中c肽水平随时间的变化,并讨论了其在临床环境中的解释。我们回顾了目前关于c肽水平与抗糖尿病药物反应之间关系的证据,以及c肽检测在T2D治疗策略中的应用。我们还回顾了c肽在预测T2D预后方面的现有证据。在这篇综述中,我们希望阐明c肽检测在理解和管理T2D方面的价值,并强调需要进一步研究的领域。
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来源期刊
Diabetic Medicine
Diabetic Medicine 医学-内分泌学与代谢
CiteScore
7.20
自引率
5.70%
发文量
229
审稿时长
3-6 weeks
期刊介绍: Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”
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