Long-span delivery of differentiable hybrid robots for restoration of neural connections

IF 17.3 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Matter Pub Date : 2025-01-13 DOI:10.1016/j.matt.2024.101942
Jie Shen, Yun Wang, Min Yao, Shubo Liu, Zhiguang Guo, Li Zhang, Ben Wang
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Abstract

Lumbar puncture is a minimally invasive technique for delivering drugs into cerebrospinal fluid (CSF). However, its effectiveness is limited by the spine’s extensive length and the narrow, complex CSF spaces, which hinder efficient passive diffusion of therapeutic agents. Here, we have engineered a differentiable stem cell-assembled soft robot (SCASR) by using a three-dimensional self-assembly process in liquid marbles. These biologically viable robots can interface with the tissues inside the CSF, adapting to the complex surroundings while navigating. With X-ray imaging and magnetic actuation, the SCASRs can be guided toward targeted regions. The SCASRs autonomously disassemble into individual cells, which then differentiate into neural cells to facilitate the restoration of neural connections, thereby aiding the recovery of paralyzed lower limbs. The proposed strategy provides an imaging-based therapeutic system for nerve injury, enabling accessibility of hard-to-reach spinal regions and facilitating efficient therapy in minimally invasive manner, by means of soft microrobots.

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用于神经连接恢复的可微混合机器人的大跨度交付
腰椎穿刺是一种将药物送入脑脊液(CSF)的微创技术。然而,其有效性受到脊柱长度和狭窄、复杂的脑脊液间隙的限制,这阻碍了治疗剂的有效被动扩散。在这里,我们设计了一个可分化的干细胞组装软机器人(SCASR),通过在液体大理石中使用三维自组装过程。这些生物上可行的机器人可以与脑脊液内的组织结合,在导航时适应复杂的环境。通过x射线成像和磁驱动,scasr可以被引导到目标区域。SCASRs自主分解成单个细胞,然后分化成神经细胞,促进神经连接的恢复,从而帮助瘫痪的下肢恢复。该策略为神经损伤提供了一种基于成像的治疗系统,使难以到达的脊柱区域能够进入,并通过软微型机器人以微创方式促进有效的治疗。
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来源期刊
Matter
Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
26.30
自引率
2.60%
发文量
367
期刊介绍: Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.
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