Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity.

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomacromolecules Pub Date : 2025-01-13 DOI:10.1021/acs.biomac.4c01464

Srishti Chakraborty, Souvik Debnath, Kailas Mahipal Malappuram, Sampath Parasuram, Huan-Tsung Chang, Kaushik Chatterjee, Amit Nain

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Abstract

Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage is limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via a solvent casting method and cross-linked in an alkaline solution. Sodium hydroxide facilitated deprotonation, leading to increased intramolecular hydrogen bonding and mechanical properties. The CHT film remained intact for 30 days in aqueous environments. A systematic study revealed a gradual increase in the output voltage from 0.9 to 1.8 V under external force (1-16 N). In addition, the CHT film showed remarkable antibacterial and anti-inflammatory activities under ultrasound stimulation and inhibition of inflammatory cytokines. The CHT films also displayed enhanced cellular proliferation and ∼5-fold faster migration of NIH3T3 cells under US stimulation. Overall, this work presents a robust, biocompatible, and wearable CHT device that can transform biomechanical energy into electrical pulses for the modulation of cell fate processes and other bioactivities.

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具有增强生物活性的柔韧而坚固的壳聚糖压电薄膜

壳聚糖（CHT）是一种已知的压电生物高分子；然而，它的使用受到限制，因为它在水系统中会迅速降解。本文采用溶剂浇铸法制备CHT薄膜，并在碱性溶液中交联。氢氧化钠促进去质子化，导致分子内氢键和机械性能的增加。CHT膜在水环境中保持完整30天。系统研究发现，在外力（1-16 N）作用下，CHT膜的输出电压从0.9 V逐渐升高到1.8 V。此外，在超声刺激和炎症因子抑制下，CHT膜表现出显著的抗菌和抗炎活性。CHT薄膜还显示，在US刺激下，细胞增殖增强，NIH3T3细胞的迁移速度快了约5倍。总的来说，这项工作提出了一个强大的、生物相容的、可穿戴的CHT装置，它可以将生物机械能转化为电脉冲，用于调节细胞命运过程和其他生物活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.