B Lymphocyte—A Prognostic Indicator in Post-Acute Pancreatitis Diabetes Mellitus

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2025-01-12 DOI:10.1111/1753-0407.70047

Xiaoyan Lin, Xiaoling Li, Junsheng Wang, Huiheng Liu

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Abstract

Objective

To determine the value of lymphocyte subsets and granulocyte/monocyte surface markers in predicting the risk of post-acute pancreatitis diabetes (PPDM-A).

Methods

This study included 308 in patients with acute pancreatitis (AP). The markers of granulocytes and monocytes and lymphocyte subsets were detected by flow cytometry, and the fluorescence intensity, absolute count and percentage were obtained. Based on the occurrence of diabetes after AP, patients were divided into two groups: PPDM-A and PPNG-A (post-acute pancreatitis with normal glucose). Correlations between granulocyte and monocyte surface markers and lymphocyte subsets were analyzed. Binary logistic regression was used to analyze the potential influencing factors of PPDM-A.

Results

Compared with patients with PPNG-A, patients with PPDM-A tend to be younger (p < 0.001) and have a higher proportion of fatty liver, recurrent pancreatitis, and hyperlipidemic pancreatitis. The results of linear regression showed that B% was negatively correlated with MFI of HLA-DR on monocytes (R² = 0.145, p < 0.001), B% was positively correlated with CD10⁻NEUT% (R² = 0.291, p < 0.001), and MFI of HLA-DR on monocytes was negatively correlated with CD10⁻NEUT% (R² = 0.457, p < 0.001). Multivariate logistic regression analysis revealed that age, serous effusion, fatty liver, recurrent pancreatitis, and B% were independent risk factors for the occurrence of PPDM-A.

Conclusion

Our study has first confirmed the correlation between PPDM-A and lymphocyte subsets and CD10⁻NEUT%. Furthermore we indicated that age, fatty liver, serous effusion, recurrent AP, and B% were independent risk factors for PPDM-A. The mechanism of granulocyte and monocyte surface markers and B lymphocytes on PPDM-A is worthy of study. This would help clarify the pathogenesis of PPDM-A at the cellular level and potentially provide new strategies for immunotherapy and even disease prevention. [Correction added on 24 January 2025, after first online publication: the third subtitle in Abstract section has been changed to ‘Results’.]

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B淋巴细胞- a在急性胰腺炎后糖尿病中的预后指标。

目的：探讨淋巴细胞亚群和粒细胞/单核细胞表面标志物对急性胰腺炎后糖尿病（PPDM-A）发病风险的预测价值。方法：本研究纳入308例急性胰腺炎（AP）患者。流式细胞术检测粒细胞、单核细胞和淋巴细胞亚群的标志物，获得荧光强度、绝对计数和百分比。根据AP后糖尿病的发生情况，将患者分为PPDM-A组和PPNG-A组（血糖正常的急性胰腺炎后）。分析了粒细胞和单核细胞表面标记物与淋巴细胞亚群之间的相关性。采用二元logistic回归分析PPDM-A的潜在影响因素。方法：与PPNG-A患者相比，PPDM-A患者倾向于年轻化（p 2 = 0.145, p -NEUT%） (R2 = 0.291, p -NEUT% （R2 = 0.457, p）。结论：本研究首次证实PPDM-A与淋巴细胞亚群和CD10-NEUT%之间存在相关性。此外，我们指出年龄、脂肪肝、浆液积液、复发性AP和B%是PPDM-A的独立危险因素。粒细胞、单核细胞表面标志物和B淋巴细胞对PPDM-A的作用机制值得研究。这将有助于在细胞水平上阐明PPDM-A的发病机制，并可能为免疫治疗甚至疾病预防提供新的策略。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.