Dietary Reference Intakes of Selenium for Chinese Residents.

IF 3.7 3区 医学 Q2 NUTRITION & DIETETICS Journal of Nutrition Pub Date : 2025-01-10 DOI:10.1016/j.tjnut.2025.01.008
Feng Han, Yiqun Liu, Qin Wang, Zhenwu Huang
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Abstract

The plasma selenoprotein P (SELENOP) concentration leveling out was thought to represent saturation of the functional selenium body pool and an appropriate supply of selenium to all tissues, indicating that the necessary amount of selenium had been supplied. Based on the selenium intake when SELENOP reaches saturation, the estimated average requirement of selenium was set as 50 μg/d, and the recommended nutrient intake was 60 μg/d for Chinese general population. According to a recent study, "lactating Chinese women with the optimal daily selenium intake" was defined, and the adequate intake of 0‒6-mo-old infants was set as 15 μg/d, whereas 20 μg/d was calculated for 7‒12 mo old infants. Considering the negative health effects of intake of excessive nutrient levels of selenium, we recommend reducing the tolerable upper intake level (UL) for adults from 400 to 255 μg/d based on the results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT). The SELECT trial is a key basis for setting selenium's UL. It has a large sample size and long-term design. It rigorously measures selenium intake and monitors multiple health endpoints precisely. Also, with proper control groups, it effectively determines the threshold of adverse effects, enhancing the reliability of UL determination.

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中国居民硒的膳食参考摄入量。
血浆硒蛋白P (SELENOP)浓度趋于平稳,表明机体功能硒池饱和,硒在各组织中得到了适当的供应,表明硒得到了必要的供应。根据SELENOP达到饱和时的硒摄入量,设定中国普通人群硒的估计平均需取量(EAR)为50 μg/d,推荐营养素摄入量(RNI)为60 μg/d。根据最近的一项研究,定义了“中国哺乳期妇女每日最佳硒摄入量”,并将0-6个月婴儿的足够摄入量(AI)设定为15 μg/d, 7-12个月婴儿的足够摄入量(AI)计算为20 μg/d。考虑到营养水平过高的硒对健康的负面影响,我们建议根据硒和维生素E癌症预防试验(SELECT)的结果,将成人的可耐受最高摄入量(UL)从400 μg/d降低到255 μg/d。SELECT试验是设置selenium的UL的关键基础。它具有大样本量和长期设计。严格测量硒摄入量,并精确监测多个健康终点。通过适当的对照组,有效地确定了不良反应的阈值,提高了UL测定的可靠性。
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来源期刊
Journal of Nutrition
Journal of Nutrition 医学-营养学
CiteScore
7.60
自引率
4.80%
发文量
260
审稿时长
39 days
期刊介绍: The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.
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