The association between lipid-related obesity indicators and severe headache or migraine: a nationwide cross sectional study from NHANES 1999 to 2004.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2025-01-11 DOI:10.1186/s12944-025-02432-w

Xu Sun, Jimei Song, Rixun Yan, Jianwei Diao, Yibo Liu, Zhangzhi Zhu, Weichi Lu

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Abstract

Background: The connection between lipid-related obesity indices and severe headache or migraine in young and middle-aged people aged 20-60 remains ambiguous, and there are gaps in the discriminative ability of different indicators for severe headaches or migraines. Consequently, we set out to look into this association utilizing National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2004.

Methods: After the values of waist-to-height ratio (WHtR), body-mass index (BMI), body roundness index (BRI), visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose index (TyG), cardiac metabolism index (CMI), waist triglyceride Index (WTI), conicity index (CI) and weight-adjusted waist index (WWI) were estimated, with minimal sufficient adjustment for confounders determined by directed acyclic graph (DAG), weighted univariable and multivariable logistic regression analyses were carried out to ascertain the relationship between them and migraine. Stratified analysis and cross-effect analysis were implemented to examine the variability of intergroup correlations. Restricted cubic splines (RCS) and receiver operating characteristic (ROC) were then employed to examine nonliner relationships and its discriminatory ability for severe headache or migraine, respectively.

Results: 3354 United States adults were involved in our study, of whom 839 (25.01%) had severe headache or migraine. After adjusting for relevant covariables, WHtR, BRI, BMI, LAP, WTI and VAI were all associated with migraine and WHtR (OR = 6.38, 95% CI: 2.25,18.09, P < 0.01) showed the best predictive ability. Additionally, WHtR, BMI, and BRI demonstrated linear dose-response relationships with the prevalence of migraine (all P_overall < 0.05, P_{non-linearity} > 0.05).

Conclusions: Among those ten lipid-related obesity indicators evaluated in the study, WHtR, BMI and BRI demonstrated linear positive dose-response relationships with the prevalence of migraine in young and middle-aged individuals within the United States and WHtR showed the best predictive ability. Our study can provide important insight into epidemiological research and comprehensive management of obese patients with migraine.

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脂质相关肥胖指标与严重头痛或偏头痛之间的关系：NHANES 1999年至2004年的全国横断面研究。

背景：脂质相关肥胖指标与20-60岁中青年严重头痛或偏头痛的关系尚不明确，不同指标对严重头痛或偏头痛的判别能力存在空白。因此，我们开始利用1999年至2004年国家健康与营养调查（NHANES）的数据来研究这种联系。方法:腰高比（WHtR）、体质量指数（BMI）、体圆度指数（BRI）、内脏脂肪指数（VAI）、脂质积累积（LAP）、甘油三酯葡萄糖指数（TyG）、心脏代谢指数（CMI）、腰围甘油三酯指数（WTI）、圆度指数（CI）和体重调整腰围指数（WWI）的值估算完成后，对有向无环图（DAG）确定的混杂因素进行了最小程度的调整。进行加权单变量和多变量logistic回归分析，以确定它们与偏头痛之间的关系。采用分层分析和交叉效应分析来检验组间相关性的可变性。然后采用限制性三次样条（RCS）和受试者工作特征（ROC）分别检验严重头痛或偏头痛的非线性关系及其区分能力。结果：3354名美国成年人参与了我们的研究，其中839人（25.01%）患有严重的头痛或偏头痛。校正相关协变量后，WHtR、BRI、BMI、LAP、WTI和VAI均与偏头痛和WHtR相关（OR = 6.38, 95% CI: 2.25、18.09，P总体< 0.05，P非线性> 0.05）。结论：在研究评估的10个脂质相关肥胖指标中，WHtR、BMI和BRI与美国中青年偏头痛患病率呈线性正剂量反应关系，WHtR具有最佳预测能力。我们的研究为肥胖偏头痛患者的流行病学研究和综合管理提供了重要的见解。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.