Innovative anticancer molecule andrographolide: a concise review of its pharmacological targets.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-01-11 DOI:10.1080/14786419.2025.2450783

Venu Sharma, Gourav Kumar, Parveen Kumar, Rajni Khajuria, Meena Nemiwal

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Abstract

Labdane diterpenoid lactone andrographolide has gained attention in medicinal research due to its potential anticancer properties in terms of suppression of the growth, propagation, and relocation of various types of cancerous cells. The current review provides deep insight into the pharmacological analysis of the anticancer secondary metabolite andrographolide. We have attempted to keep an overview on the interaction of promising drugs like ligand molecule andrographolide with various biological targets. The observation indicates that andrographolide significantly down-regulates the growth of cancer cells through various mechanisms via diminishing inducible nitric oxide synthase (iNOS) expression, attenuating Akt and JNK signalling cascade, inhibiting NF-κB activation, ROS generation in the neoplastic cells etc. This bio-molecule is a potent therapeutic agent that can be applied in treating and preventing inflammatory vascular diseases. This study may be beneficial in the area of drug development research, leading to better management of cancer and many other inflammatory diseases.

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创新抗癌分子穿心莲内酯：其药理靶点的简明综述。

兰丹二萜内酯穿心莲内酯具有抑制多种类型癌细胞生长、繁殖和迁移的潜在抗癌特性，在医学研究中受到广泛关注。本文综述了抗癌次生代谢产物穿心莲内酯的药理分析。本文就穿心莲内酯等有前景的药物与多种生物靶点的相互作用作一综述。结果表明，穿心莲内酯通过降低诱导型一氧化氮合酶（iNOS）表达、减弱Akt和JNK信号级联、抑制NF-κB活化、抑制肿瘤细胞ROS生成等多种机制，显著下调肿瘤细胞的生长。该生物分子是一种有效的治疗药物，可用于治疗和预防炎症性血管疾病。这项研究可能有助于药物开发研究领域，从而更好地管理癌症和许多其他炎症性疾病。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.