Relationships between Chronic Cough and Asthma Control and Quality-of-Life in Patients with Severe Asthma: A 6-Month Longitudinal Analysis.

IF 8.2 1区医学 Q1 ALLERGY Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-01-10 DOI:10.1016/j.jaip.2025.01.006

Hwa Young Lee, Youngsoo Lee, Seung-Eun Lee, Da Woon Sim, Noeul Kang, Byung-Jae Lee, Joo-Hee Kim, Sung-Yoon Kang, Sujeong Kim, Ji Hyun Oh, Kyoung-Hee Sohn, Hye-Kyung Park, So Ri Kim, Min-Hye Kim, Han-Ki Park, So-Young Park, Jae-Woo Kwon, Hae-Sim Park, Sang-Heon Kim, You Sook Cho, Kian Fan Chung, Woo-Jung Song

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Abstract

Background: The prevalence and clinical implications of chronic cough (CC) in patients with severe asthma receiving asthma treatment remain relatively unknown.

Objective: This study aimed to evaluate the relationships between CC and asthma control and quality-of-life (QoL) in patients with severe asthma through longitudinal analysis.

Methods: Baseline and 6-month follow-up data from the Korean Severe Asthma Registry were analyzed. CC was defined as a cough visual analog scale (VAS) score of ≥40 at both baseline and 6-months. Demographic parameters and clinical outcomes were compared between patients with severe asthma and CC and those without CC. Generalized estimating equation (GEE) analysis was performed to identify associations of CC with asthma control and QoL scores.

Results: Of the total 286 participants with severe asthma, 116 (40.6%) were defined as having CC. Patients with CC had higher baseline cough and wheeze severity VAS scores (all P<0.001), poorer asthma control (P<0.001), and worse QoL (Severe Asthma Questionnaire [SAQ] and Euro-QoL 5-dimension [EQ-5D] index, all P<0.001), compared to those without CC. During follow-up, patients with CC were more frequently exposed to oral corticosteroids (58.6% vs. 38.6%, P=0.010) and experienced more frequent asthma exacerbations (48.3% vs. 28.6%, P=0.009) than those without CC. GEE analysis revealed that CC was independently associated with poor asthma control, lower SAQ scores, and lower EQ-5D index after adjusting for confounders.

Conclusion: The presence of CC was associated with worse asthma control and QoL in patients with severe asthma. Further studies are warranted to better evaluate and manage CC in these patients.

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背景：在接受哮喘治疗的重症哮喘患者中，慢性咳嗽（CC）的发病率和临床影响仍相对未知：本研究旨在通过纵向分析评估慢性咳嗽与重症哮喘患者的哮喘控制和生活质量（QoL）之间的关系：方法：分析韩国重症哮喘登记处的基线数据和 6 个月的随访数据。基线和 6 个月的咳嗽视觉模拟量表（VAS）评分≥40 分即为 CC。对患有重症哮喘并伴有CC的患者和不伴有CC的患者的人口统计学参数和临床结果进行了比较。通过广义估计方程（GEE）分析，确定了CC与哮喘控制和QoL评分之间的关系：在286名重症哮喘患者中，有116人（40.6%）被定义为患有CC。CC患者的基线咳嗽和喘息严重程度VAS评分较高（均为PC）：CC的存在与重症哮喘患者的哮喘控制和生活质量下降有关。有必要开展进一步研究，以便更好地评估和管理这些患者的CC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Allergy and Clinical Immunology-In Practice ALLERGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

11.10

自引率

9.60%

发文量

683

审稿时长

50 days

期刊介绍： JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases. This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders. The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.