Real-time dose measurement in minibeam radiotherapy using radioluminescence imaging

IF 3.3 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Physica Medica-European Journal of Medical Physics Pub Date : 2025-02-01 DOI:10.1016/j.ejmp.2025.104894
Francesca Marson , Stefano Pizzardi , Lisa Alborghetti , Federica Vurro , Maria Assunta Lacavalla , Claudio Fiorino , Antonello E. Spinelli
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引用次数: 0

Abstract

Purpose:

Minibeam radiotherapy (MBRT) uses small parallel beams of radiation to create a highly modulated dose pattern. The aim of this study is to develop an optical radioluminescence imaging (RLI) approach to perform real-time dose measurement for MBRT.

Methods:

MBRT was delivered using an image-guided small animal irradiator equipped with a custom collimator. Five slabs of plastic scintillators with a thicknesses of 0.5, 1, 2, 3 and 10 mm were placed on top of a mouse phantom, to localize and measure the delivered dose. A thin radioluminescence film (Gd2O2S:Tb) was used to obtain the mini beam dose profile that was compared against GafChromic (GC) films measurements. The RLI signal was detected with a CMOS camera placed at 90 deg with respect to the beam axis. Monte Carlo (MC) simulations were also performed using TOPAS for comparison with the experimental results.

Results:

The measured peak to valley dose ratio (PVDR) obtained with RLI was 16.7 in line with GC films measurements. The differences between peak and valley dimension were less that 3% with respect to GC measurements. Using RLI performed with the scintillator slabs, it was possible to localize and measure in real-time MBRT delivery on the mouse phantom.

Conclusions:

We proposed a novel method for MBRT dose localization and measurement in real-time based on RLI. The results we obtained are in good agreement with GC film measurements.
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放射发光成像在微束放射治疗中的实时剂量测量。
目的:微束放射治疗(MBRT)使用小的平行辐射束来产生高度调制的剂量模式。本研究的目的是开发一种光学放射发光成像(RLI)方法,用于MBRT的实时剂量测量。方法:使用配备定制准直器的图像引导小动物辐照器进行MBRT传递。将厚度分别为0.5、1、2、3和10 mm的5块塑料闪烁体板放置在小鼠幻体上,用于定位和测量给药剂量。用一层薄薄的放射发光膜(Gd2O2S:Tb)获得了微束剂量谱,并与GafChromic (GC)薄膜测量结果进行了比较。RLI信号被放置在与光束轴90度的CMOS相机检测到。利用TOPAS进行了蒙特卡罗(MC)模拟,与实验结果进行了比较。结果:RLI法测得的峰谷剂量比(PVDR)为16.7,与气相膜测定值一致。相对于GC测量,峰谷尺寸之间的差异小于3%。使用闪烁体板进行RLI,可以定位和测量实时MBRT在小鼠幻体上的传递。结论:我们提出了一种基于RLI的MBRT剂量定位和实时测量的新方法。所得结果与气相色谱膜测量值吻合较好。
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来源期刊
CiteScore
6.80
自引率
14.70%
发文量
493
审稿时长
78 days
期刊介绍: Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.
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