TiO2 and PbTiO3 assisted SPR biosensor for detection of malignancy in human-liver tissue with high sensitivity and figure of merit

IF 2.2 4区工程技术 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Journal of Computational Electronics Pub Date : 2025-01-13 DOI:10.1007/s10825-025-02277-7

Laxmi Jaiswal, Adarsh Chandra Mishra, Sapana Yadav, Pooja Lohia, D. K. Dwivedi, R. K. Yadav, Upendra Kulshrestha, Ammar M. Tighezza, M. Khalid Hossain

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Abstract

A high performance Kretschmann configuration-based surface plasmons resonance (SPR) biosensor is proposed for the detection of hepatocellular carcinoma (HCC) liver tissues. The proposed structure consists of calcium fluoride (CaF₂) prism, silver (Ag) metal, and a heterojunction of titanium dioxide (TiO₂), lead titanate (PbTiO₃), and molybdenum di selenide (MoSe₂). Role of constituents materials is analyzed in terms of their contribution towards enhancement in the performance. At near infrared wavelength of 1000 nm, the thickness and number of layers of constituent layers is optimized in the light of practical realization. The proposed biosensor provides an ultrahigh sensitivity of 486 deg/RIU with a full-width half maximum (FWHM) of 1.0720 degrees and a figure of merits (FoM) of 453.35 RIU⁻¹. Further, the corresponding power-loss ratio is also calculated. Hence, the combined performance factor for the proposed sensor is 480.56 RIU⁻¹. The novelty of the work relies in the design and selection of material (especially TiO₂ and PbTiO₃) that offers the highest possible values of performance parameters for prism based sensor in the best of our knowledge.

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TiO2和PbTiO3辅助SPR生物传感器检测人肝组织恶性肿瘤具有高灵敏度和优值图

提出了一种基于Kretschmann构型的表面等离子体共振（SPR）生物传感器，用于肝细胞癌（HCC）的肝组织检测。所提出的结构由氟化钙（CaF2）棱镜、银（Ag）金属和二氧化钛（TiO2）、钛酸铅（PbTiO3）和二硒化钼（MoSe2）的异质结组成。根据组成材料对提高性能的贡献，分析了它们的作用。在近红外波长1000 nm处，结合实际实现，对组成层的厚度和层数进行了优化。所提出的生物传感器提供了486度/RIU的超高灵敏度，全宽半最大值（FWHM）为1.0720度，优点系数（FoM）为453.35 RIU−1。此外，还计算了相应的功率损耗比。因此，所提出的传感器的综合性能因子为480.56 RIU−1。这项工作的新颖性依赖于材料的设计和选择（特别是TiO2和PbTiO3），这些材料为我们所知的棱镜传感器提供了最高的性能参数值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Computational Electronics ENGINEERING, ELECTRICAL & ELECTRONIC-PHYSICS, APPLIED

CiteScore

4.50

自引率

4.80%

发文量

142

审稿时长

>12 weeks

期刊介绍： he Journal of Computational Electronics brings together research on all aspects of modeling and simulation of modern electronics. This includes optical, electronic, mechanical, and quantum mechanical aspects, as well as research on the underlying mathematical algorithms and computational details. The related areas of energy conversion/storage and of molecular and biological systems, in which the thrust is on the charge transport, electronic, mechanical, and optical properties, are also covered. In particular, we encourage manuscripts dealing with device simulation; with optical and optoelectronic systems and photonics; with energy storage (e.g. batteries, fuel cells) and harvesting (e.g. photovoltaic), with simulation of circuits, VLSI layout, logic and architecture (based on, for example, CMOS devices, quantum-cellular automata, QBITs, or single-electron transistors); with electromagnetic simulations (such as microwave electronics and components); or with molecular and biological systems. However, in all these cases, the submitted manuscripts should explicitly address the electronic properties of the relevant systems, materials, or devices and/or present novel contributions to the physical models, computational strategies, or numerical algorithms.