Ultrasensitive photoelectrochemical detection of cancer markers based on heterojunctions constructed from Bi₂O₃ star-like flower nanoclusters and CdS hollow nanorods.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL Talanta Pub Date : 2025-01-09 DOI:10.1016/j.talanta.2025.127563

Zimeng Wang, Jiawei Wang, Jingchun Ou, Xianbiao Hu, Minglun Wei, Zinan Chen, Rongshan Lin, Jianying Yang, Wenhua Gao

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Abstract

CYFRA21-1 is a tumor marker for lung cancer, and its rapid and accurate detection can provide evidence for the early diagnosis of lung cancer. In this work, Bi-Fe turnbull blue analogues (Bi-Fe-TBA) were synthesized by the self-templating method. Bi₂O₃-SFNs was prepared by simple oxidation in air using Bi-Fe-TBA as a template. Bi₂O₃ Star-like Flower Nanoclusters (Bi₂O₃-SFNs) and CdS Hollow Nanorods (CdS-HNRs) were used to form a unique type II heterojunction for the first time. The arrangement of energy levels between CdS-HNRs and Bi₂O₃-SFNs, along with their hollow structure and star shape, effectively suppressed the recombination of photogenerated electrons and holes while shortening carrier transport distance. An ultra-sensitive PEC biosensor was developed to detect the lung cancer marker CYFRA21-1, leveraging the superior photoelectric conversion capabilities of Bi₂O₃-SFNs/CdS-HNRs. The sensor demonstrates outstanding stability, specificity, reproducibility as well as a wide linear range (10^-4 - 10 ng mL^-1) and low detection limit (4.23 × 10^-5 ng mL^-1). This study is valuable for the preparation of other functional materials using TBA as a template.

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CYFRA21-1 是肺癌的肿瘤标志物，其快速准确的检测可为肺癌的早期诊断提供证据。本研究采用自串联法合成了 Bi-Fe Turnbull 蓝类似物（Bi-Fe-TBA）。以 Bi-Fe-TBA 为模板，在空气中通过简单氧化制备出 Bi2O3-SFNs 。Bi2O3 星状花纳米团簇（Bi2O3-SFNs）和 CdS 空心纳米棒（CdS-HNRs）首次形成了独特的 II 型异质结。CdS-HNRs 和 Bi2O3-SFNs 之间的能级排列以及它们的中空结构和星形形状有效地抑制了光生电子和空穴的重组，同时缩短了载流子传输距离。利用 Bi2O3-SFNs/CdS-HNRs 卓越的光电转换能力，开发了一种超灵敏的 PEC 生物传感器，用于检测肺癌标志物 CYFRA21-1。该传感器具有出色的稳定性、特异性和再现性，线性范围宽（10-4 - 10 ng mL-1），检测限低（4.23 × 10-5 ng mL-1）。这项研究对于以 TBA 为模板制备其他功能材料具有重要价值。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.