Towards a unified approach in managing resistance to vaccines, drugs, and pesticides

IF 11.7 1区 生物学 Q1 BIOLOGY Biological Reviews Pub Date : 2025-01-14 DOI:10.1111/brv.13174
Andrei V. Alyokhin, Benjamin M. Rosenthal, Donald C. Weber, Mitchell B. Baker
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Abstract

Everywhere, pests and pathogens evolve resistance to our control efforts, impairing human health and welfare. Developing sustainable solutions to this problem requires working with evolved immune and ecological systems, rather than against these evolutionary forces. We advocate a transdisciplinary approach to resistance based on an evolutionary foundation informed by the concepts of integrated pest management and One Health. Diverse, multimodal management approaches create a more challenging environment for the evolution of resistance. Given our permanent evolutionary and ecological relationships with pests and pathogens, responses to most biological threats to health and agriculture should seek sustainable harm reduction rather than eradication.

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在管理对疫苗、药物和杀虫剂的耐药性方面采取统一办法。
在世界各地,害虫和病原体对我们的控制努力产生了抗药性,损害了人类的健康和福祉。为这一问题制定可持续的解决办法需要与进化的免疫系统和生态系统合作,而不是与这些进化的力量对抗。我们提倡基于综合病虫害管理和一个健康概念的进化基础上的跨学科方法来抵抗。多样化、多模式的管理方法为耐药性的演变创造了更具挑战性的环境。鉴于我们与病虫害和病原体之间永恒的进化和生态关系,应对健康和农业面临的大多数生物威胁应寻求可持续地减少危害,而不是根除危害。
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来源期刊
Biological Reviews
Biological Reviews 生物-生物学
CiteScore
21.30
自引率
2.00%
发文量
99
审稿时长
6-12 weeks
期刊介绍: Biological Reviews is a scientific journal that covers a wide range of topics in the biological sciences. It publishes several review articles per issue, which are aimed at both non-specialist biologists and researchers in the field. The articles are scholarly and include extensive bibliographies. Authors are instructed to be aware of the diverse readership and write their articles accordingly. The reviews in Biological Reviews serve as comprehensive introductions to specific fields, presenting the current state of the art and highlighting gaps in knowledge. Each article can be up to 20,000 words long and includes an abstract, a thorough introduction, and a statement of conclusions. The journal focuses on publishing synthetic reviews, which are based on existing literature and address important biological questions. These reviews are interesting to a broad readership and are timely, often related to fast-moving fields or new discoveries. A key aspect of a synthetic review is that it goes beyond simply compiling information and instead analyzes the collected data to create a new theoretical or conceptual framework that can significantly impact the field. Biological Reviews is abstracted and indexed in various databases, including Abstracts on Hygiene & Communicable Diseases, Academic Search, AgBiotech News & Information, AgBiotechNet, AGRICOLA Database, GeoRef, Global Health, SCOPUS, Weed Abstracts, and Reaction Citation Index, among others.
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