Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) - The Onco-SOL Ancillary Study.

IF 3.7 3区医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2025-01-14 DOI:10.1158/1055-9965.EPI-24-1325

Humberto Parada, Ilir Agalliu, Daniela Sotres-Alvarez, Andrew F Olshan, Kelly R Evenson, Thomas E Rohan, Robert C Kaplan, Caroline A Thompson, Linda C Gallo, Frank J Penedo, Jianwen Cai, Sylvia Wassertheil-Smoller, Bharat Thyagarajan, Stefani N Thomas, Olga L Garcia-Bedoya, Martha L Daviglus, Gregory A Talavera

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Abstract

Background: Few studies have examined how cancer incidence varies by country of origin among United States Hispanic/Latino adults. Herein, we describe the incidence rates of cancer overall and for screen-detectable, tobacco-related, and obesity-related cancers among 16,415 participants in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), an ongoing population-based cohort study of Hispanic/Latino adults from diverse backgrounds.

Methods: Cohort participant records were linked to the state cancer registries in New York, Florida, California, and Illinois to ascertain cancer incidence from baseline (2008-2011) through 2021. We estimated weighted age-adjusted incidence rates (IRs), and age- and sex-adjusted hazard ratios (HRs).

Results: Over a mean follow-up of 10.7 (SD=2.0) years, 715 incident invasive cancers were diagnosed including 118 female breast, 102 prostate, and 79 bronchus and lung cancers. The IR of all cancers combined was 26.2 [95% confidence interval (CI)=22.6-30.2] per 10,000 (10K) person-years (py). The IRs were lowest among persons of Mexican descent [IR=19.0 (95%CI=15.0-24.1) per 10K-py] and highest for those of Puerto Rican [IR=36.6 (95%CI=28.4-47.0) per 10K-py] descent. Compared to those of Mexican descent, those of Puerto Rican, Cuban, and Dominican descent had higher hazards of cancer incidence; the incidence of obesity-related (HR=2.37; 95%CI=1.43-3.95) and tobacco-related (HR=3.00; 95%CI=1.58-5.71) cancers were also the highest among Puerto Ricans.

Conclusions: Cancer incidence rates varied by Hispanic/Latino heritage and were masked when Hispanics/Latinos were aggregated into a single group.

Impact: Understanding disparities in cancer risk by Hispanic/Latino heritage may help tailor cancer prevention and control strategies.

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西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）的癌症发病率- Onco-SOL辅助研究

背景：很少有研究调查了美国西班牙裔/拉丁裔成年人的癌症发病率如何因原籍国而异。在此，我们描述了西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）中16,415名参与者的癌症发病率，以及筛查可检测的、烟草相关的和肥胖相关的癌症发病率，这是一项正在进行的基于不同背景的西班牙裔/拉丁裔成年人的人群队列研究。方法：队列参与者的记录与纽约州、佛罗里达州、加利福尼亚州和伊利诺伊州的州癌症登记处相关联，以确定从基线（2008-2011年）到2021年的癌症发病率。我们估计了加权年龄调整发生率（IRs）以及年龄和性别调整风险比（hr）。结果：在平均10.7 （SD=2.0）年的随访中，诊断出715例侵袭性癌症，其中女性乳腺癌118例，前列腺癌102例，支气管和肺癌79例。所有癌症的IR合计为26.2[95%可信区间(CI)=22.6-30.2] / 10,000 （10K）人年（py）。IR在墨西哥裔人群中最低[IR=19.0 (95%CI=15.0-24.1) / 10K-py]，在波多黎各裔人群中最高[IR=36.6 (95%CI=28.4-47.0) / 10K-py]。与墨西哥裔相比，波多黎各裔、古巴裔和多米尼加裔患癌症的风险更高；与肥胖相关的发病率(HR=2.37；95%CI=1.43-3.95)和烟草相关(HR=3.00；95%CI=1.58-5.71)癌症在波多黎各人中也是最高的。结论：癌症发病率因西班牙裔/拉丁裔血统而异，当西班牙裔/拉丁裔聚集成一个单一组时被掩盖。影响：了解西班牙裔/拉丁裔血统的癌症风险差异可能有助于制定癌症预防和控制策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.