MiRNAs as major players in brain health and disease: current knowledge and future perspectives.

IF 6.1 2区生物学 Q1 CELL BIOLOGY Cell Death Discovery Pub Date : 2025-01-13 DOI:10.1038/s41420-024-02283-x

Sarika V Kapplingattu, Sujata Bhattacharya, Yogita K Adlakha

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Abstract

MicroRNAs are regulators of gene expression and their dysregulation can lead to various diseases. MicroRNA-135 (MiR-135) exhibits brain-specific expression, and performs various functions such as neuronal morphology, neural induction, and synaptic function in the human brain. Dysfunction of miR-135 has been reported in brain tumors, and neurodegenerative and neurodevelopmental disorders. Several reports show downregulation of miR-135 in glioblastoma, indicating its tumor suppressor role in the pathogenesis of brain tumors. In this review, by performing in silico analysis of molecular targets of miR-135, we reveal the significant pathways and processes modulated by miR-135. We summarize the biological significance, roles, and signaling pathways of miRNAs in general, with a focus on miR-135 in different neurological diseases including brain tumors, and neurodegenerative and neurodevelopmental disorders. We also discuss methods, limitations, and potential of glioblastoma organoids in recapitulating disease initiation and progression. We highlight the promising therapeutic potential of miRNAs as antitumor agents for aggressive human brain tumors including glioblastoma.

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mirna作为脑健康和疾病的主要参与者：当前的知识和未来的观点。

MicroRNAs是基因表达的调控因子，其失调可导致多种疾病。MicroRNA-135 （MiR-135）具有脑特异性表达，在人脑中具有神经元形态学、神经诱导和突触功能等多种功能。miR-135的功能障碍在脑肿瘤、神经退行性和神经发育障碍中有报道。一些报道显示miR-135在胶质母细胞瘤中下调，表明其在脑肿瘤发病机制中的抑瘤作用。在这篇综述中，通过对miR-135的分子靶点进行硅分析，我们揭示了miR-135调节的重要途径和过程。我们总结了mirna的生物学意义、作用和信号通路，重点关注miR-135在不同神经系统疾病（包括脑肿瘤、神经退行性和神经发育障碍）中的作用。我们还讨论了胶质母细胞瘤类器官在重现疾病发生和进展中的方法、局限性和潜力。我们强调了mirna作为侵袭性人脑肿瘤（包括胶质母细胞瘤）的抗肿瘤药物的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.