Platelet Indices and the Causal Relationship with Myeloid Leukemia: a Mendelian Randomization Study with Dual Samples.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2025-01-01 DOI:10.7754/Clin.Lab.2024.240733

Cong-Fa Jiang

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Abstract

Background: Platelets are correlated with myeloid leukemia (ML), but to date, there have been no studies confirming the causal relationship between them.

Methods: Platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) data were obtained from the GWAS catalog database as exposure factors. Acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) data were obtained from the FinnGen database as outcome indicators. The causal relationship between exposure and outcome was explored using the inverse variance weighted, MR-Egger, weighted median, and simple mode methods of dual-sample Mendelian randomization (MR). The stability and reliability of the results were assessed using Cochran's test, MR-Egger regression, and MR-PRESSO methods.

Results: An elevated PCT is positively associated with the risk of CML [ORMR-Egger = 2.591, 95% CI (1.089 - 6.166), p = 0.032; ORSimple mode = 9.873, 95% CI (1.112 - 87.646), p = 0.040]. There was no evidence of heterogeneity or plei-otropy at the gene level. However, there were no causal associations between other indices and CML, and none of the four platelet indices were causally associated with AML.

Conclusions: An increase in PCT significantly increases the risk of developing CML, making it a candidate biomarker for clinical screening of CML.

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血小板指数及其与髓系白血病的因果关系：双样本孟德尔随机研究。

背景：血小板与髓性白血病（ML）相关，但迄今为止，还没有研究证实两者之间的因果关系。方法：从GWAS目录数据库中获取血小板计数（PLT）、平均血小板体积（MPV）、血小板电积（PCT）和血小板分布宽度（PDW）数据作为暴露因素。急性髓性白血病（AML）和慢性髓性白血病（CML）数据从FinnGen数据库获得作为结局指标。使用双样本孟德尔随机化（MR）的反方差加权、MR- egger、加权中位数和简单模式方法探讨暴露与结果之间的因果关系。使用Cochran检验、MR-Egger回归和MR-PRESSO方法评估结果的稳定性和可靠性。结果：PCT升高与CML发病风险呈正相关[ORMR-Egger = 2.591, 95% CI (1.089 ~ 6.166), p = 0.032；or简单模式= 9.873,95% CI (1.112 ~ 87.646), p = 0.040]。在基因水平上没有异质性或多效性的证据。然而，其他指标与CML之间没有因果关系，四项血小板指标均与AML无因果关系。结论：PCT的升高会显著增加CML发生的风险，使其成为CML临床筛查的候选生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.