Conversion of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma to Angioimmunoblastic T-cell Lymphoma: a Rare Case.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2025-01-01 DOI:10.7754/Clin.Lab.2024.240743

Hongjuan Yu, Xuefen Qi, Jifei Zhang, Lingrong He

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Abstract

Background: Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma (PTCL) and accounts for 2% of all non-Hodgkin lymphomas. Its typical characteristics include an aggressive course, progressive lymphadenopathy, hepatosplenomegaly, systemic symptoms, anemia, hypergammaglobulinemia, and generally poor prognosis.

Methods: We describe a rare case in which the left inguinal lymph node was completely excised and biopsied one year ago. Based on histomorphology and immunohistochemistry, B-cell small lymphocytic lymphoma (CLL/SLL) was diagnosed. Routine bone marrow examination indicated the presence of immature lymphocytes; however, immunophenotyping showed no significant abnormal lymphocytes. One month ago, the patient developed swelling in the left lower limb, which gradually worsened. A fine-needle aspiration biopsy of the left inguinal lymph node revealed angioimmunoblastic T-cell lymphoma.

Results: The final diagnosis for this patient is a transformation from B-cell small lymphocytic lymphoma to angioimmunoblastic T-cell lymphoma (AITL) one year after the initial diagnosis.

Conclusions: In this report, we present a rare case of AITL. The aim is to enhance awareness among readers regarding the clinical, immunological, and phenotypic characteristics of various forms of AITL.

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慢性淋巴细胞白血病/小淋巴细胞淋巴瘤向血管免疫母细胞t细胞淋巴瘤转化一例罕见病例。

背景：血管免疫母细胞t细胞淋巴瘤（AITL）是外周t细胞淋巴瘤（PTCL）的一种独特亚型，占所有非霍奇金淋巴瘤的2%。其典型特征包括病程侵袭性、进行性淋巴结病变、肝脾肿大、全身性症状、贫血、高γ球蛋白血症和一般预后不良。方法：我们描述了一个罕见的情况下，左侧腹股沟淋巴结完全切除和活检一年前。根据组织形态学和免疫组织化学，诊断为b细胞小淋巴细胞淋巴瘤（CLL/SLL）。常规骨髓检查提示存在未成熟淋巴细胞；免疫表型分析未见明显淋巴细胞异常。1个月前，患者左下肢出现肿胀，并逐渐加重。左侧腹股沟淋巴结细针穿刺活检显示血管免疫母细胞t细胞淋巴瘤。结果：该患者的最终诊断为b细胞小淋巴细胞淋巴瘤向血管免疫母细胞t细胞淋巴瘤（AITL）转变，最初诊断一年。结论：在本报告中，我们报告了一例罕见的AITL病例。目的是提高读者对各种形式的AITL的临床、免疫学和表型特征的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.