Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity.

IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Current Obesity Reports Pub Date : 2025-01-14 DOI:10.1007/s13679-024-00594-9
Hanghang Liu, Linyi Liu, Clifford J Rosen
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Abstract

Purpose of review: Bone marrow adipose tissue is a distinctive fat depot located within the skeleton, with the potential to influence both local and systemic metabolic processes. Although significant strides have been made in understanding bone marrow adipose tissue over the past decade, many questions remain regarding their precise lineage and functional roles.

Recent findings: Recent studies have highlighted bone marrow adipose tissue's involvement in continuous cross-talk with other organs and systems, exerting both endocrine and paracrine functions that play a crucial role in metabolic homeostasis, skeletal remodeling, hematopoiesis, and the progression of bone metastases. The advancement of imaging techniques, particularly cross-sectional imaging, has profoundly expanded our understanding of the complexities beyond the traditional view of bone marrow adipose tissue as an inert depot. Notably, marrow adipocytes are anatomically and functionally distinct from brown, beige, and classic white adipocytes. Emerging evidence suggests that bone marrow adipocytes, bone marrow adipose tissue originate from the differentiation of bone marrow mesenchymal stromal cells; however, they appear to be a heterogeneous population with varying metabolic profiles, lipid compositions, secretory properties, and functional responses depending on their specific location within the bone marrow. This review provides an up-to-date synthesis of current knowledge on bone marrow adipocytes, emphasizing the relationships between bone marrow adipogenesis and factors such as aging, osteoporosis, obesity, and bone marrow tumors or metastases, thereby elucidating the mechanisms underlying musculoskeletal pathophysiology.

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骨髓脂肪细胞作为代谢稳态的新调节因子:骨髓肥胖的临床后果。
综述目的:骨髓脂肪组织是位于骨骼内的独特脂肪库,具有影响局部和全身代谢过程的潜力。尽管在过去的十年里,人们对骨髓脂肪组织的理解取得了重大进展,但关于它们的确切谱系和功能角色,仍然存在许多问题。最近的研究发现:骨髓脂肪组织参与与其他器官和系统的持续串扰,发挥内分泌和旁分泌功能,在代谢稳态、骨骼重塑、造血和骨转移的进展中发挥重要作用。成像技术的进步,特别是横断面成像技术,已经深刻地扩展了我们对复杂性的理解,超越了骨髓脂肪组织作为惰性储存的传统观点。值得注意的是,骨髓脂肪细胞在解剖学和功能上不同于棕色、米色和典型的白色脂肪细胞。新的证据表明,骨髓脂肪细胞、骨髓脂肪组织起源于骨髓间充质间质细胞的分化;然而,它们似乎是一个异质性的群体,具有不同的代谢谱、脂质组成、分泌特性和功能反应,这取决于它们在骨髓中的特定位置。本文综述了目前关于骨髓脂肪细胞的最新知识,强调了骨髓脂肪形成与衰老、骨质疏松、肥胖、骨髓肿瘤或转移等因素之间的关系,从而阐明了肌肉骨骼病理生理的机制。
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来源期刊
Current Obesity Reports
Current Obesity Reports Medicine-General Medicine
CiteScore
16.40
自引率
1.10%
发文量
25
期刊介绍: The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.
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