Improvement of IL-4, IL-6, IL-10, TNF-α and IFN-γ in children with mycoplasma pneumonia through the combination of video scenario-based breathing training and antibiotics.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY Sleep and Breathing Pub Date : 2025-01-14 DOI:10.1007/s11325-025-03244-z

Mengqiong Zhang

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Abstract

Objective: This study aims to investigate the effects of video scenario-based breathing training on interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in children with Mycoplasma pneumonia.

Methods: A total of 106 children with Mycoplasma pneumonia treated in our hospital from February 2022 to April 2024 were selected. According to different nursing methods, children receiving routine intervention were assigned to the control group, while those undergoing video scenario-based breathing training were assigned to the training group. The serum inflammatory indexes, improvement time of clinical symptoms and lung function recovery were compared between the two groups before training, and at 1 and 2 weeks after training.

Results: Before training, there was no statistically significant difference in serum inflammatory and lung function indexes between the two groups (p > 0.05). After 1 and 2 weeks of training, the forced expiratory volume in 1 s (FEV1), peak expiratory flow rate (PEF), and the ratio of FEV1 to forced vital capacity (FEV1/FVC) in both groups increased, with higher values in the training group than in the control group, and the difference was statistically significant (p < 0.05). The time for cough disappearance, wheezing disappearance, lung rales disappearance and high fever abatement in the training group was lower than that in the control group, with statistically significant differences (p < 0.05). The levels of IL-4, IL-6, IL-10, TNF-α, and IFN-γ decreased in both groups, with lower levels in the training group than in the control group, and the difference was statistically significant (p < 0.05).

Conclusion: Video scenario-based breathing training can improve lung function, alleviate clinical symptoms and signs, and reduce serum inflammatory levels of IL-4, IL-6, IL-10, TNF-α and IFN-γ in children with Mycoplasma pneumonia.

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视频场景呼吸训练联合抗生素对肺炎支原体患儿IL-4、IL-6、IL-10、TNF-α、IFN-γ的改善

目的：本研究旨在探讨视频场景呼吸训练对肺炎支原体患儿白细胞介素-4 （IL-4）、白细胞介素-6 （IL-6）、白细胞介素-10 （IL-10）、肿瘤坏死因子-α (TNF-α)、干扰素-γ (IFN-γ)的影响。方法：选取2022年2月~ 2024年4月我院收治的肺炎支原体患儿106例。根据护理方式的不同，接受常规干预的患儿为对照组，接受视频场景呼吸训练的患儿为训练组。比较两组在训练前、训练后1、2周的血清炎症指标、临床症状改善时间及肺功能恢复情况。结果：训练前，两组患者血清炎症指标、肺功能指标比较，差异均无统计学意义（p < 0.05）。训练1、2周后，两组患者1秒用力呼气量（FEV1）、呼气峰流量（PEF）、FEV1/用力肺活量（FEV1/FVC）均升高，训练组高于对照组，差异有统计学意义(p)。视频场景呼吸训练可改善肺炎支原体患儿肺功能，缓解临床症状和体征，降低血清IL-4、IL-6、IL-10、TNF-α和IFN-γ的炎症水平。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.