Evaluation of Inflammatory Activity of Extraocular Muscles in Thyroid Associated Orbitopathy by [⁶⁸Ga]DOTATATE PET/CT.

IF 3 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Molecular Imaging and Biology Pub Date : 2025-02-01 Epub Date: 2025-01-14 DOI:10.1007/s11307-024-01970-6

Zhengquan Hu, Jinyan Liu, Haoyu Deng, Na Chen, Lu Chen, Sha Wang, Tingting Long, Jia Tan, Shuo Hu

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Abstract

Purpose: The accurate assessment of inflammatory activity of the extraocular muscles (EOMs) in thyroid associated ophthalmopathy (TAO) is crucial for formulating subsequent treatment strategies and prognostic judgments. This study aims to explore the efficacy of using [⁶⁸Ga]DOTATATE PET/CT to assess the inflammatory activity of EOMs in TAO patients.

Procedures: This study enrolled 22 TAO patients and 6 healthy volunteers, all of whom underwent orbital [⁶⁸Ga]DOTATATE PET/CT. Among these, 18 patients underwent orbital [^99mTc]DTPA SPECT/CT within one week, and the other 4 patients received orbital MRI. All imaging data were independently assessed, followed by comparative data analysis. The patients then received different treatment schemes, and their prognosis was followed up.

Results: [⁶⁸Ga]DOTATATE PET/CT could effectively evaluate the inflammatory activity of the EOMs in TAO patients and demonstrate good consistency with [^99mTc]DTPA SPECT/CT and orbital MRI, but show a better resolution to distinguish EOMs and surrounding structure. The receiver operating characteristic (ROC) curves for each EOM, treated as individual research units, exhibited an area under the curve (AUC) exceeding 0.9. The medial rectus demonstrated the highest involvement and diagnostic accuracy(AUC = 0.976, P < 0.001). Patients treated with glucocorticoids showed significantly higher SUVmax in EOMs compared to those receiving symptomatic treatment (P < 0.01).

Conclusions: [⁶⁸Ga]DOTATATE PET/CT is a reliable method for assessing the inflammatory activity of EOMs in TAO patients, providing strong objective evidence for the precise diagnosis and treatment.

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[68Ga]DOTATATE PET/CT评价甲状腺相关性眼病眼外肌炎症活动性。

目的：准确评估甲状腺相关性眼病（TAO）眼外肌（EOMs）的炎症活性对制定后续治疗策略和预后判断至关重要。本研究旨在探讨使用[68Ga]DOTATATE PET/CT评估TAO患者EOMs炎症活性的有效性。方法：本研究纳入22例TAO患者和6名健康志愿者，均行眶[68Ga]DOTATATE PET/CT检查。其中18例患者在一周内行眼眶[99mTc]DTPA SPECT/CT检查，4例患者行眼眶MRI检查。所有影像资料独立评估，然后进行对比数据分析。患者接受不同的治疗方案，并随访预后。结果：[68Ga]DOTATATE PET/CT能有效评价TAO患者eom的炎症活动性，与[99mTc]DTPA SPECT/CT和眼眶MRI具有较好的一致性，但在区分eom和周围结构方面分辨率较好。每个EOM的受试者工作特征（ROC）曲线被视为单独的研究单元，曲线下面积（AUC）超过0.9。结论：[68Ga]DOTATATE PET/CT是评估TAO患者EOMs炎症活动性的可靠方法，为准确诊断和治疗提供了有力的客观证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.