Influence of sex in the development of liver diseases.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Seminars in liver disease Pub Date : 2025-01-14 DOI:10.1055/a-2516-0261

Jie-Wen Zhang, Nan Zhang, Yi Lyu, Xu-Feng Zhang

{"title":"Influence of sex in the development of liver diseases.","authors":"Jie-Wen Zhang, Nan Zhang, Yi Lyu, Xu-Feng Zhang","doi":"10.1055/a-2516-0261","DOIUrl":null,"url":null,"abstract":"<p><p>The liver is a sexually dimorphic organ. Sex differences in prevalence, progression, prognosis and treatment do prevail in most liver diseases, and the mechanism of how liver diseases act differently among male versus female patients have not been fully elucidated. Biological sex differences in normal physiology and disease arise principally from sex hormones and/or sex chromosomes. Sex hormones contribute to development and progression of most liver diseases, with estrogen- and androgen-mediated signaling pathways mechanistically involved. In addition, genetic factors in sex chromosomes have recently been found contributing to the sex disparity of many liver diseases, which might explain to some extent the difference in gene expression pattern, immune response and xenobiotic metabolism between men and women. Although increasing evidence suggests that sex is one of the most important modulators of disease prevalence and outcomes, at present, basic and clinical studies has long been sex unbalanced, with female subjects underestimated. As such, this review focus on sex disparities of liver diseases and summarizes current understanding of sex specific mechanisms, including sex hormones, sex chromosome, etc. We anticipate that understanding sex-specific pathogenesis will aid in promoting personalized therapies of liver disease among male versus female patients.</p>","PeriodicalId":21724,"journal":{"name":"Seminars in liver disease","volume":" ","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in liver disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2516-0261","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The liver is a sexually dimorphic organ. Sex differences in prevalence, progression, prognosis and treatment do prevail in most liver diseases, and the mechanism of how liver diseases act differently among male versus female patients have not been fully elucidated. Biological sex differences in normal physiology and disease arise principally from sex hormones and/or sex chromosomes. Sex hormones contribute to development and progression of most liver diseases, with estrogen- and androgen-mediated signaling pathways mechanistically involved. In addition, genetic factors in sex chromosomes have recently been found contributing to the sex disparity of many liver diseases, which might explain to some extent the difference in gene expression pattern, immune response and xenobiotic metabolism between men and women. Although increasing evidence suggests that sex is one of the most important modulators of disease prevalence and outcomes, at present, basic and clinical studies has long been sex unbalanced, with female subjects underestimated. As such, this review focus on sex disparities of liver diseases and summarizes current understanding of sex specific mechanisms, including sex hormones, sex chromosome, etc. We anticipate that understanding sex-specific pathogenesis will aid in promoting personalized therapies of liver disease among male versus female patients.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

性别对肝脏疾病发展的影响。

肝脏是一个具有性别差异的器官。大多数肝病在发病率、病情发展、预后和治疗方面确实存在性别差异，而肝病在男性和女性患者之间产生不同作用的机制尚未完全阐明。正常生理和疾病的生物性别差异主要来自性激素和/或性染色体。性激素对大多数肝病的发生和发展起着重要作用，雌激素和雄激素介导的信号传导途径是其中的机理。此外，最近还发现性染色体的遗传因素导致了许多肝病的性别差异，这可能在一定程度上解释了男女之间在基因表达模式、免疫反应和异生物代谢方面的差异。尽管越来越多的证据表明，性别是疾病流行和结局的最重要调节因素之一，但目前的基础和临床研究长期以来一直存在性别不平衡的问题，女性研究对象被低估。因此，本综述重点关注肝病的性别差异，并总结目前对性别特异性机制的理解，包括性激素、性染色体等。我们预计，对性别特异性发病机制的了解将有助于促进对男性和女性肝病患者的个性化治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Seminars in liver disease 医学-胃肠肝病学

CiteScore

8.20

自引率

2.40%

发文量

期刊介绍： Seminars in Liver Disease is a quarterly review journal that publishes issues related to the specialties of hepatology and gastroenterology. As the premiere review journal in the field, Seminars in Liver Disease provides in-depth coverage with articles and issues focusing on topics such as cirrhosis, transplantation, vascular and coagulation disorders, cytokines, hepatitis B & C, Nonalcoholic Steatosis Syndromes (NASH), pediatric liver diseases, hepatic stem cells, porphyrias as well as a myriad of other diseases related to the liver. Attention is also given to the latest developments in drug therapy along with treatment and current management techniques. Seminars in Liver Disease publishes commissioned reviews. Unsolicited reviews of an exceptional nature or original articles presenting remarkable results will be considered, but case reports will not be published.

期刊最新文献

Current Concepts in Fluid Resuscitation and Vasopressor Use in Cirrhosis. Influence of sex in the development of liver diseases. Extracellular Vesicles and Micro-RNAs in Liver Disease. Alcohol Plus Additional Risk Factors: Rodent Model of Liver Injury. LncRNAs, RNA Therapeutics, and Emerging Technologies in Liver Pathobiology.