Framework Nucleic Acid-Based and Neutrophil-Based Nanoplatform Loading Baicalin with Targeted Drug Delivery for Anti-Inflammation Treatment

IF 15.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY ACS Nano Pub Date : 2025-01-16 DOI:10.1021/acsnano.4c12917

Mi Zhou, Yuanlin Tang, Yifei Lu, Tianxu Zhang, Shunhao Zhang, Xiaoxiao Cai, Yunfeng Lin

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Abstract

Targeted drug delivery is a promising strategy for treating inflammatory diseases, with recent research focusing on the combination of neutrophils and nanomaterials. In this study, a targeted nanodrug delivery platform (Ac-PGP-tFNA, APT) was developed using tetrahedral framework nucleic acid (tFNA) along with a neutrophil hitchhiking mechanism to achieve precise delivery and anti-inflammatory effects. The tFNA structure, known for its excellent drug-loading capacity and cellular uptake efficiency, was used to carry a therapeutic agent─baicalin. The results demonstrate that the development of this drug delivery platform not only considerably enhances the bioavailability and effective concentration of the drug (baicalin) but also promotes the polarization of pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages by modulating the interactions between the neutrophils and macrophages. This targeted therapeutic method effectively treats inflammatory conditions such as sepsis and introduces a strategy for managing inflammatory diseases characterized by neutrophil infiltration.

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基于核酸和中性粒细胞的框架纳米平台负载黄芩苷靶向给药抗炎治疗

靶向药物递送是治疗炎症性疾病的一种很有前途的策略，最近的研究重点是中性粒细胞和纳米材料的结合。本研究利用四面体框架核酸（tFNA）和中性粒细胞搭便车机制，开发了一种靶向纳米药物递送平台（Ac-PGP-tFNA， APT），以实现精准递送和抗炎作用。以其优异的载药能力和细胞摄取效率而闻名的tFNA结构被用来携带一种治疗剂─黄芩苷。结果表明，该给药平台的开发不仅显著提高了黄芩苷的生物利用度和有效浓度，而且通过调节中性粒细胞和巨噬细胞之间的相互作用，促进促炎M1巨噬细胞向抗炎M2巨噬细胞的极化。这种靶向治疗方法有效地治疗了脓毒症等炎症性疾病，并引入了一种以中性粒细胞浸润为特征的炎症性疾病的管理策略。

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来源期刊

ACS Nano 工程技术-材料科学：综合

CiteScore

26.00

自引率

4.10%

发文量

1627

审稿时长

1.7 months

期刊介绍： ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.