Non-contact electroacoustic tomography with optical interferometer for electroporation therapy monitoring

IF 3.5 2区 物理与天体物理 Q2 PHYSICS, APPLIED Applied Physics Letters Pub Date : 2025-01-17 DOI:10.1063/5.0244192
Yifei Xu, Yuchen Song, Leshan Sun, Zhongping Chen, Liangzhong Xiang
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Abstract

Electroacoustic imaging is an imaging modality used to detect electric field energy distribution during electroporation, offering valuable guidance for clinical procedures, particularly in deep tissues. Traditionally, single-element piezoelectric transducers or arrays have been employed for this purpose. However, these piezoelectric sensors are sensitive to electromagnetic interference and require physical contact with the sample through a coupling medium, raising concerns for both clinical and preclinical applications. To overcome these limitations, a multi-channel random quadrature ultrasonics system has been developed, enabling non-contact detection of electroacoustic signals. In this study, we demonstrated that this non-contact technique effectively detects electroacoustic signals, identifies electroporation regions, and reconstructs electric energy distribution, offering a promising approach for monitoring electroporation therapy.
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用光学干涉仪进行电穿孔治疗监测的非接触式电声断层扫描
电声成像是一种成像方式,用于检测电穿孔过程中的电场能量分布,为临床程序提供有价值的指导,特别是在深部组织中。传统上,单元件压电换能器或阵列已被用于此目的。然而,这些压电传感器对电磁干扰很敏感,并且需要通过耦合介质与样品进行物理接触,这引起了临床和临床前应用的关注。为了克服这些限制,开发了一种多通道随机正交超声系统,实现了对电声信号的非接触检测。在这项研究中,我们证明了这种非接触式技术可以有效地检测电声信号,识别电穿孔区域,并重建电能分布,为监测电穿孔治疗提供了一种很有前途的方法。
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来源期刊
Applied Physics Letters
Applied Physics Letters 物理-物理:应用
CiteScore
6.40
自引率
10.00%
发文量
1821
审稿时长
1.6 months
期刊介绍: Applied Physics Letters (APL) features concise, up-to-date reports on significant new findings in applied physics. Emphasizing rapid dissemination of key data and new physical insights, APL offers prompt publication of new experimental and theoretical papers reporting applications of physics phenomena to all branches of science, engineering, and modern technology. In addition to regular articles, the journal also publishes invited Fast Track, Perspectives, and in-depth Editorials which report on cutting-edge areas in applied physics. APL Perspectives are forward-looking invited letters which highlight recent developments or discoveries. Emphasis is placed on very recent developments, potentially disruptive technologies, open questions and possible solutions. They also include a mini-roadmap detailing where the community should direct efforts in order for the phenomena to be viable for application and the challenges associated with meeting that performance threshold. Perspectives are characterized by personal viewpoints and opinions of recognized experts in the field. Fast Track articles are invited original research articles that report results that are particularly novel and important or provide a significant advancement in an emerging field. Because of the urgency and scientific importance of the work, the peer review process is accelerated. If, during the review process, it becomes apparent that the paper does not meet the Fast Track criterion, it is returned to a normal track.
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