Crystalline porous frameworks (MOF@COF) for adsorption-desorption analysis of β-lactam drugs

Abstract

This article presents the synthesis of a porous hybrid material, comprising a melamine-terephthaldehyde-based two-dimensional π-conjugated covalent organic framework (COF) grown on a zinc-based metal-organic framework-5 (MOF-5). This hybrid material serves as a drug-loading platform for delivering penicillin G sodium salt. The material leverages the unique interactions between its benzene ring structure and β-lactam drugs, such as penicillin G sodium salt, as well as π-π stacking interactions, cations, and aromatic systems for drug adsorption. The pH responsiveness of the release phase is attributed to the attack of hydrogen ions on these interactions within the corrosion inhibition system. SEM, infrared spectrometry, and X-ray diffraction results confirm the successful synthesis of MOF@COFs. Drug adsorption experiments indicate that the material’s maximum loading capacity reaches 51.23% ± 0.57. Release experiments at different pH levels reveal that MOF@COFs exhibit pH responsiveness, achieving an optimal release rate and duration at pH 5.0, with a release time of approximately 12 hours. Bacterial and biological toxicity tests confirm the material’s expected antibacterial efficacy and safety for practical applications.