Zhiyuan Wang , Yali Li , Xuena Ding , Yuancheng Sun , Chongchong Chen , Wei Sun , Xiangdong Hu
{"title":"DNDMH enabled C(sp3)–H nitration of aryl alkenes†","authors":"Zhiyuan Wang , Yali Li , Xuena Ding , Yuancheng Sun , Chongchong Chen , Wei Sun , Xiangdong Hu","doi":"10.1039/d4cc06671e","DOIUrl":null,"url":null,"abstract":"<div><div>C(sp<sup>3</sup>)–H bond nitration provides facile access to nitro compounds that are inaccessible through traditional nitration pathways. This work describes a C(sp<sup>3</sup>)–H bond nitration of aryl alkenes using DNDMH, a nitration reagent developed previously in our lab. Notably, this novel nitration process presents excellent regioselectivity and chemoselectivity between C(sp<sup>3</sup>)–H nitration and C(sp<sup>2</sup>)–H nitration.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"61 15","pages":"Pages 3147-3150"},"PeriodicalIF":4.2000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734525001429","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
C(sp3)–H bond nitration provides facile access to nitro compounds that are inaccessible through traditional nitration pathways. This work describes a C(sp3)–H bond nitration of aryl alkenes using DNDMH, a nitration reagent developed previously in our lab. Notably, this novel nitration process presents excellent regioselectivity and chemoselectivity between C(sp3)–H nitration and C(sp2)–H nitration.
期刊介绍:
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