Yaoyu Liang, Jie Luo, Cai You, Yael Diskin-Posner, David Milstein
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引用次数: 0
Abstract
Using water as a hydrogen or oxygen source in organic synthesis has enabled various reductive and oxidative transformations, but incorporation of both hydrogen and oxygen atoms into the same molecule, representing an atom-economic and environmentally benign process, has scarcely been explored. Here we report a hydrogenative oxidation strategy using water as both a source of H2 and formal oxidant, enabling the direct synthesis of lactams from N-heteroarenes and thereby eliminating the need for additional reductants and oxidants and minimizing waste generation. The reaction can be initiated either under low H2 pressure or with a catalytic amount of H2, leading to the efficient transformation of various N-heteroarenes into lactams in excellent yield thanks to an in situ-generated, piperidine-based, ruthenium pincer complex that balances the hydrogenation and dehydrogenation processes. This study will promote the design of other hydrogenative oxidation reactions using water.
期刊介绍：
Nature Catalysis serves as a platform for researchers across chemistry and related fields, focusing on homogeneous catalysis, heterogeneous catalysis, and biocatalysts, encompassing both fundamental and applied studies. With a particular emphasis on advancing sustainable industries and processes, the journal provides comprehensive coverage of catalysis research, appealing to scientists, engineers, and researchers in academia and industry.
Maintaining the high standards of the Nature brand, Nature Catalysis boasts a dedicated team of professional editors, rigorous peer-review processes, and swift publication times, ensuring editorial independence and quality. The journal publishes work spanning heterogeneous catalysis, homogeneous catalysis, and biocatalysis, covering areas such as catalytic synthesis, mechanisms, characterization, computational studies, nanoparticle catalysis, electrocatalysis, photocatalysis, environmental catalysis, asymmetric catalysis, and various forms of organocatalysis.
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