{"title":"Beyond housekeeping: a new role of snoRNA in nascent protein secretion","authors":"Hao Wu, Chu-Xiao Liu, Ling-Ling Chen","doi":"10.1038/s41422-024-01070-8","DOIUrl":null,"url":null,"abstract":"<p><b>Although small nucleolar RNAs (snoRNAs) are well-known for guiding 2′-</b><b><i>O</i></b><b>-methylation and pseudouridine modification on ribosomal RNAs and small nuclear RNAs, their additional functions have remained largely undefined. Liu and colleagues developed snoKARR-seq to map transcriptome-wide snoRNA targets, and discovered an unexpected role of snoRNA:</b> <b><i>SNORA73</i></b> <b>simultaneously binds to the target mRNA and the</b> <b><i>7SL</i></b> <b>RNA of the signal recognition particle to form ternary interactions that facilitate the secretion of the encoded protein</b>.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"101 1","pages":""},"PeriodicalIF":28.1000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-024-01070-8","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Although small nucleolar RNAs (snoRNAs) are well-known for guiding 2′-O-methylation and pseudouridine modification on ribosomal RNAs and small nuclear RNAs, their additional functions have remained largely undefined. Liu and colleagues developed snoKARR-seq to map transcriptome-wide snoRNA targets, and discovered an unexpected role of snoRNA:SNORA73simultaneously binds to the target mRNA and the7SLRNA of the signal recognition particle to form ternary interactions that facilitate the secretion of the encoded protein.
期刊介绍：
Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.
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