{"title":"Dual HATs-mediated Catalyst-free sp3 C-H Bond Functionalization for Regioselective Radical Hydroalkylation of Ynazoles","authors":"Yu-Xin Wu, Xiang Chen, Bang-Yan Ou, Qian Yan, Si-Han Chen, Ya-Wen Zhao, Zhi-Wei Li, Han-Wen Liu, Jiang-Sheng Li","doi":"10.1002/adsc.202401372","DOIUrl":null,"url":null,"abstract":"Direct hydroalkylation of ynazoles, facilitating the efficient synthesis of linear N-β-vinylazoles, is accomplished through the functionalization of sp3 C-H bonds using trace amounts of dioxygen as an initiator. This reagent-free method eliminates the need for exogenous reagents and proceeds through a radical chain mechanism involving dual hydrogen atom transfer (HAT) processes. Its application potential is exemplified through the implementation of scale-up operations.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"32 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202401372","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Direct hydroalkylation of ynazoles, facilitating the efficient synthesis of linear N-β-vinylazoles, is accomplished through the functionalization of sp3 C-H bonds using trace amounts of dioxygen as an initiator. This reagent-free method eliminates the need for exogenous reagents and proceeds through a radical chain mechanism involving dual hydrogen atom transfer (HAT) processes. Its application potential is exemplified through the implementation of scale-up operations.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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